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The ontogeny of drug metabolizing enzymes and transporters in the rat.
de Zwart L, Scholten M, Monbaliu JG, Annaert PP, Van Houdt JM, Van den Wyngaert I, De Schaepdrijver LM, Bailey GP, Coogan TP, Coussement WC, Mannens GS. de Zwart L, et al. Among authors: van houdt jm, van den wyngaert i. Reprod Toxicol. 2008 Nov-Dec;26(3-4):220-30. doi: 10.1016/j.reprotox.2008.09.010. Epub 2008 Oct 7. Reprod Toxicol. 2008. PMID: 18926897
Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?
Kreir M, Van Deuren B, Versweyveld S, De Bondt A, Van den Wyngaert I, Van der Linde H, Lu HR, Teuns G, Gallacher DJ. Kreir M, et al. Among authors: van den wyngaert i, van deuren b, van der linde h. Toxicol Appl Pharmacol. 2018 May 1;346:45-57. doi: 10.1016/j.taap.2018.03.028. Epub 2018 Mar 26. Toxicol Appl Pharmacol. 2018. PMID: 29596924
Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.
Verbist BM, Verheyen GR, Vervoort L, Crabbe M, Beerens D, Bosmans C, Jaensch S, Osselaer S, Talloen W, Van den Wyngaert I, Van Hecke G, Wuyts D; QSTAR Consortium; Van Goethem F, Göhlmann HW. Verbist BM, et al. Among authors: van goethem f, van den wyngaert i, van hecke g. Chem Res Toxicol. 2015 Oct 19;28(10):1914-25. doi: 10.1021/acs.chemrestox.5b00103. Epub 2015 Sep 15. Chem Res Toxicol. 2015. PMID: 26313431 Free article.
Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment.
Lambertz I, Kumps C, Claeys S, Lindner S, Beckers A, Janssens E, Carter DR, Cazes A, Cheung BB, De Mariano M, De Bondt A, De Brouwer S, Delattre O, Gibbons J, Janoueix-Lerosey I, Laureys G, Liang C, Marchall GM, Porcu M, Takita J, Trujillo DC, Van Den Wyngaert I, Van Roy N, Van Goethem A, Van Maerken T, Zabrocki P, Cools J, Schulte JH, Vialard J, Speleman F, De Preter K. Lambertz I, et al. Among authors: van maerken t, van den wyngaert i, van roy n, van goethem a. Clin Cancer Res. 2015 Jul 15;21(14):3327-39. doi: 10.1158/1078-0432.CCR-14-2024. Epub 2015 Mar 24. Clin Cancer Res. 2015. PMID: 25805801
MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.
Beke L, Kig C, Linders JT, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M. Beke L, et al. Among authors: van den wyngaert i, van eynde a, van heerde e. Biosci Rep. 2015 Oct 2;35(6):e00267. doi: 10.1042/BSR20150194. Biosci Rep. 2015. PMID: 26431963 Free PMC article.
Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Kopljar I, Gallacher DJ, De Bondt A, Cougnaud L, Vlaminckx E, Van den Wyngaert I, Lu HR. Kopljar I, et al. Among authors: van den wyngaert i. Stem Cells Transl Med. 2016 May;5(5):602-12. doi: 10.5966/sctm.2015-0279. Epub 2016 Mar 31. Stem Cells Transl Med. 2016. PMID: 27034410 Free PMC article.
41 results