Hellinga HW - Search Results

1

Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle.

Smith AJ, Müller R, Toscano MD, Kast P, Hellinga HW, Hilvert D, Houk KN. Smith AJ, et al. Among authors: hellinga hw. J Am Chem Soc. 2008 Nov 19;130(46):15361-73. doi: 10.1021/ja803213p. Epub 2008 Oct 22. J Am Chem Soc. 2008. PMID: 18939839 Free PMC article.

2

Design of a calcium-binding protein with desired structure in a cell adhesion molecule.

Yang W, Wilkins AL, Ye Y, Liu ZR, Li SY, Urbauer JL, Hellinga HW, Kearney A, van der Merwe PA, Yang JJ. Yang W, et al. Among authors: hellinga hw. J Am Chem Soc. 2005 Feb 23;127(7):2085-93. doi: 10.1021/ja0431307. J Am Chem Soc. 2005. PMID: 15713084

3

Rational design of a calcium-binding protein.

Yang W, Jones LM, Isley L, Ye Y, Lee HW, Wilkins A, Liu ZR, Hellinga HW, Malchow R, Ghazi M, Yang JJ. Yang W, et al. Among authors: hellinga hw. J Am Chem Soc. 2003 May 21;125(20):6165-71. doi: 10.1021/ja034724x. J Am Chem Soc. 2003. PMID: 12785848

4

Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design.

Mabanglo MF, Hast MA, Lubock NB, Hellinga HW, Beese LS. Mabanglo MF, et al. Among authors: hellinga hw. Protein Sci. 2014 Mar;23(3):289-301. doi: 10.1002/pro.2411. Epub 2014 Jan 31. Protein Sci. 2014. PMID: 24347326 Free PMC article.

5

Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.

Shi Y, Hellinga HW, Beese LS. Shi Y, et al. Among authors: hellinga hw. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6010-6015. doi: 10.1073/pnas.1704845114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533382 Free PMC article.

6

Computational design of a biologically active enzyme.

Dwyer MA, Looger LL, Hellinga HW. Dwyer MA, et al. Among authors: hellinga hw. Science. 2004 Jun 25;304(5679):1967-71. doi: 10.1126/science.1098432. Science. 2004. Retraction in: Science. 2008 Feb 1;319(5863):569. doi: 10.1126/science.319.5863.569b PMID: 15218149 Retracted.

7

Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides.

Wang W, Wu EY, Hellinga HW, Beese LS. Wang W, et al. Among authors: hellinga hw. J Biol Chem. 2012 Aug 17;287(34):28215-26. doi: 10.1074/jbc.M112.366609. Epub 2012 May 30. J Biol Chem. 2012. PMID: 22648417 Free PMC article.

8

The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites.

Cuneo MJ, Changela A, Warren JJ, Beese LS, Hellinga HW. Cuneo MJ, et al. Among authors: hellinga hw. J Mol Biol. 2006 Sep 15;362(2):259-70. doi: 10.1016/j.jmb.2006.06.084. Epub 2006 Aug 10. J Mol Biol. 2006. PMID: 16904687

9

Structural analysis of a periplasmic binding protein in the tripartite ATP-independent transporter family reveals a tetrameric assembly that may have a role in ligand transport.

Cuneo MJ, Changela A, Miklos AE, Beese LS, Krueger JK, Hellinga HW. Cuneo MJ, et al. Among authors: hellinga hw. J Biol Chem. 2008 Nov 21;283(47):32812-20. doi: 10.1074/jbc.M803595200. Epub 2008 Aug 22. J Biol Chem. 2008. PMID: 18723845 Free PMC article.

10

Ligand-induced conformational changes in a thermophilic ribose-binding protein.

Cuneo MJ, Beese LS, Hellinga HW. Cuneo MJ, et al. Among authors: hellinga hw. BMC Struct Biol. 2008 Nov 19;8:50. doi: 10.1186/1472-6807-8-50. BMC Struct Biol. 2008. PMID: 19019243 Free PMC article.

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