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Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.
Scarpelli R, Di Marco A, Ferrigno F, Laufer R, Marcucci I, Muraglia E, Ontoria JM, Rowley M, Serafini S, Steinkühler C, Jones P. Scarpelli R, et al. Among authors: serafini s. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6078-82. doi: 10.1016/j.bmcl.2008.10.041. Epub 2008 Oct 12. Bioorg Med Chem Lett. 2008. PMID: 18952417
A series of novel, potent, and selective histone deacetylase inhibitors.
Jones P, Altamura S, Chakravarty PK, Cecchetti O, De Francesco R, Gallinari P, Ingenito R, Meinke PT, Petrocchi A, Rowley M, Scarpelli R, Serafini S, Steinkühler C. Jones P, et al. Among authors: serafini s. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5948-52. doi: 10.1016/j.bmcl.2006.09.002. Epub 2006 Sep 20. Bioorg Med Chem Lett. 2006. PMID: 16987657
Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Pescatore G, Kinzel O, Attenni B, Cecchetti O, Fiore F, Fonsi M, Rowley M, Schultz-Fademrecht C, Serafini S, Steinkühler C, Jones P. Pescatore G, et al. Among authors: serafini s. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5528-32. doi: 10.1016/j.bmcl.2008.09.003. Epub 2008 Sep 6. Bioorg Med Chem Lett. 2008. PMID: 18809328
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
Ontoria JM, Altamura S, Di Marco A, Ferrigno F, Laufer R, Muraglia E, Palumbi MC, Rowley M, Scarpelli R, Schultz-Fademrecht C, Serafini S, Steinkühler C, Jones P. Ontoria JM, et al. Among authors: serafini s. J Med Chem. 2009 Nov 12;52(21):6782-9. doi: 10.1021/jm900555u. J Med Chem. 2009. PMID: 19888759
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Ontoria JM, Bufi LL, Torrisi C, Bresciani A, Giomini C, Rowley M, Serafini S, Bin H, Hao W, Steinkühler C, Jones P. Ontoria JM, et al. Among authors: serafini s. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5274-82. doi: 10.1016/j.bmcl.2011.07.031. Epub 2011 Jul 14. Bioorg Med Chem Lett. 2011. PMID: 21803580
A high-throughput radiometric assay for hepatitis C virus NS3 protease.
Cerretani M, Di Renzo L, Serafini S, Vitelli A, Gennari N, Bianchi E, Pessi A, Urbani A, Colloca S, De Francesco R, Steinkühler C, Altamura S. Cerretani M, et al. Among authors: serafini s. Anal Biochem. 1999 Jan 15;266(2):192-7. doi: 10.1006/abio.1998.2948. Anal Biochem. 1999. PMID: 9888975
179 results