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The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway.
Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. Marinari B, et al. Among authors: moretti f. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17091-6. doi: 10.1073/pnas.0809288105. Epub 2008 Oct 28. Proc Natl Acad Sci U S A. 2008. PMID: 18957551 Free PMC article.
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.
Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, Karin M, Costanzo A. Botti E, et al. Among authors: moretti f. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13710-5. doi: 10.1073/pnas.1110931108. Epub 2011 Aug 1. Proc Natl Acad Sci U S A. 2011. PMID: 21807998 Free PMC article.
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.
Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, Garaffo G, Vernersson-Lindahl E, Merlo G, Mills AA, Ballarò C, Alemà S, Chimenti S, Guerrini L, Costanzo A. Moretti F, et al. J Clin Invest. 2010 May;120(5):1570-7. doi: 10.1172/JCI40267. Epub 2010 Apr 26. J Clin Invest. 2010. PMID: 20424325 Free PMC article.
Programmed cell death in the skin.
Costanzo A, Fausti F, Spallone G, Moretti F, Narcisi A, Botti E. Costanzo A, et al. Among authors: moretti f. Int J Dev Biol. 2015;59(1-3):73-8. doi: 10.1387/ijdb.150050ac. Int J Dev Biol. 2015. PMID: 26374528 Free article. Review.
Tumor necrosis factor (TNF) receptor 1 signaling downstream of TNF receptor-associated factor 2. Nuclear factor kappaB (NFkappaB)-inducing kinase requirement for activation of activating protein 1 and NFkappaB but not of c-Jun N-terminal kinase/stress-activated protein kinase.
Natoli G, Costanzo A, Moretti F, Fulco M, Balsano C, Levrero M. Natoli G, et al. Among authors: moretti f. J Biol Chem. 1997 Oct 17;272(42):26079-82. doi: 10.1074/jbc.272.42.26079. J Biol Chem. 1997. PMID: 9334169 Free article.
373 results