Kilford PJ - Search Results

1

Toward an improved prediction of human in vivo brain penetration.

Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD. Summerfield SG, et al. Among authors: kilford pj. Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459. Xenobiotica. 2008. PMID: 18979396

2

Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models.

Gardner I, Xu M, Han C, Wang Y, Jiao X, Jamei M, Khalidi H, Kilford P, Neuhoff S, Southall R, Turner DB, Musther H, Jones B, Taylor S. Gardner I, et al. Xenobiotica. 2022 Aug;52(8):943-956. doi: 10.1080/00498254.2022.2132426. Xenobiotica. 2022. PMID: 36222269 Free article.

3

Physiologically-Based Pharmacokinetic Models of CYP2D6 Substrate and Inhibitors Nebivolol, Cinacalcet and Mirabegron to Simulate Drug-Drug Interactions.

Kilford P, Khoshaein N, Southall R, Gardner I. Kilford P, et al. Eur J Drug Metab Pharmacokinet. 2022 Sep;47(5):699-710. doi: 10.1007/s13318-022-00775-8. Epub 2022 Jul 15. Eur J Drug Metab Pharmacokinet. 2022. PMID: 35840839

4

A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates.

Arora S, Pansari A, Kilford PJ, Jamei M, Turner DB, Gardner I. Arora S, et al. Among authors: kilford pj. Eur J Drug Metab Pharmacokinet. 2022 Jul;47(4):483-495. doi: 10.1007/s13318-022-00765-w. Epub 2022 Apr 29. Eur J Drug Metab Pharmacokinet. 2022. PMID: 35486324

5

Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions.

Arora S, Pansari A, Kilford P, Jamei M, Gardner I, Turner DB. Arora S, et al. Mol Pharm. 2020 Jul 6;17(7):2329-2344. doi: 10.1021/acs.molpharmaceut.0c00043. Epub 2020 Jun 1. Mol Pharm. 2020. PMID: 32427480

6

Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.

Zhang M, Fisher C, Gardner I, Pan X, Kilford P, Bois FY, Jamei M. Zhang M, et al. Drug Metab Dispos. 2022 Jul;50(7):957-967. doi: 10.1124/dmd.121.000818. Epub 2022 May 3. Drug Metab Dispos. 2022. PMID: 35504655

7

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

Kilford PJ, Chen KF, Crewe K, Gardner I, Hatley O, Ke AB, Neuhoff S, Zhang M, Rowland Yeo K. Kilford PJ, et al. CPT Pharmacometrics Syst Pharmacol. 2022 Jul;11(7):822-832. doi: 10.1002/psp4.12794. Epub 2022 Apr 28. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35445542 Free PMC article.

8

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.

Kilford PJ, Gertz M, Houston JB, Galetin A. Kilford PJ, et al. Drug Metab Dispos. 2008 Jul;36(7):1194-7. doi: 10.1124/dmd.108.020834. Epub 2008 Apr 14. Drug Metab Dispos. 2008. PMID: 18411401

9

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters.

Achour B, Al-Majdoub ZM, Grybos-Gajniak A, Lea K, Kilford P, Zhang M, Knight D, Barber J, Schageman J, Rostami-Hodjegan A. Achour B, et al. Clin Pharmacol Ther. 2021 Jan;109(1):222-232. doi: 10.1002/cpt.2102. Epub 2020 Nov 25. Clin Pharmacol Ther. 2021. PMID: 33141922 Free PMC article.

10

Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.

Gertz M, Kilford PJ, Houston JB, Galetin A. Gertz M, et al. Among authors: kilford pj. Drug Metab Dispos. 2008 Mar;36(3):535-42. doi: 10.1124/dmd.107.018713. Epub 2007 Dec 20. Drug Metab Dispos. 2008. PMID: 18096674

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