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Page 1
Toward an improved prediction of human in vivo brain penetration.
Summerfield SG, Lucas AJ, Porter RA, Jeffrey P, Gunn RN, Read KR, Stevens AJ, Metcalf AC, Osuna MC, Kilford PJ, Passchier J, Ruffo AD. Summerfield SG, et al. Among authors: porter ra. Xenobiotica. 2008 Dec;38(12):1518-35. doi: 10.1080/00498250802499459. Xenobiotica. 2008. PMID: 18979396
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
Porter RA, Chan WN, Coulton S, Johns A, Hadley MS, Widdowson K, Jerman JC, Brough SJ, Coldwell M, Smart D, Jewitt F, Jeffrey P, Austin N. Porter RA, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10. doi: 10.1016/s0960-894x(01)00343-2. Bioorg Med Chem Lett. 2001. PMID: 11459658
Orexin-A, an hypothalamic peptide with analgesic properties.
Bingham S, Davey PT, Babbs AJ, Irving EA, Sammons MJ, Wyles M, Jeffrey P, Cutler L, Riba I, Johns A, Porter RA, Upton N, Hunter AJ, Parsons AA. Bingham S, et al. Among authors: porter ra. Pain. 2001 May;92(1-2):81-90. doi: 10.1016/s0304-3959(00)00470-x. Pain. 2001. PMID: 11323129
N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.
Boyd HF, Fell SC, Flynn ST, Hickey DM, Ife RJ, Leach CA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Porter RA, Rawlings DA, Smith SA, Stansfield IG, Tew DG, Theobald CJ, Whittaker CM. Boyd HF, et al. Among authors: porter ra. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2557-61. doi: 10.1016/s0960-894x(00)00510-2. Bioorg Med Chem Lett. 2000. PMID: 11086729
Acylglycinamides as inhibitors of glycine transporter type 1.
Blunt R, Porter R, Johns A, Nash D, Puckey G, Wyman P, Herdon H, Teague S, Hadden V, Fontana S, Gordon L. Blunt R, et al. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6176-9. doi: 10.1016/j.bmcl.2011.07.096. Epub 2011 Aug 6. Bioorg Med Chem Lett. 2011. PMID: 21889344
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N. Hagan JJ, et al. Among authors: porter ra. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10911-6. doi: 10.1073/pnas.96.19.10911. Proc Natl Acad Sci U S A. 1999. PMID: 10485925 Free PMC article.
67 results