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Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
Batinić-Haberle I, Ndengele MM, Cuzzocrea S, Rebouças JS, Spasojević I, Salvemini D. Batinić-Haberle I, et al. Among authors: ndengele mm. Free Radic Biol Med. 2009 Jan 15;46(2):212-9. doi: 10.1016/j.freeradbiomed.2008.09.037. Epub 2008 Oct 17. Free Radic Biol Med. 2009. PMID: 18983908 Free PMC article.
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D. Ndengele MM, et al. J Pharmacol Exp Ther. 2009 Apr;329(1):64-75. doi: 10.1124/jpet.108.146290. Epub 2008 Nov 25. J Pharmacol Exp Ther. 2009. PMID: 19033555 Free PMC article.
A newly identified role for superoxide in inflammatory pain.
Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E, Muscoli C, Mollace V, Ndengele M, Ischiropoulos H, Salvemini D. Wang ZQ, et al. J Pharmacol Exp Ther. 2004 Jun;309(3):869-78. doi: 10.1124/jpet.103.064154. Epub 2004 Feb 26. J Pharmacol Exp Ther. 2004. PMID: 14988418
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