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Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.
Batinić-Haberle I, Ndengele MM, Cuzzocrea S, Rebouças JS, Spasojević I, Salvemini D. Batinić-Haberle I, et al. Among authors: salvemini d. Free Radic Biol Med. 2009 Jan 15;46(2):212-9. doi: 10.1016/j.freeradbiomed.2008.09.037. Epub 2008 Oct 17. Free Radic Biol Med. 2009. PMID: 18983908 Free PMC article.
Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.
Batinić-Haberle I, Cuzzocrea S, Rebouças JS, Ferrer-Sueta G, Mazzon E, Di Paola R, Radi R, Spasojević I, Benov L, Salvemini D. Batinić-Haberle I, et al. Among authors: salvemini d. Free Radic Biol Med. 2009 Jan 15;46(2):192-201. doi: 10.1016/j.freeradbiomed.2008.09.042. Epub 2008 Nov 1. Free Radic Biol Med. 2009. PMID: 19007878 Free PMC article.
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
Tovmasyan AG, Rajic Z, Spasojevic I, Reboucas JS, Chen X, Salvemini D, Sheng H, Warner DS, Benov L, Batinic-Haberle I. Tovmasyan AG, et al. Among authors: salvemini d. Dalton Trans. 2011 Apr 28;40(16):4111-21. doi: 10.1039/c0dt01321h. Epub 2011 Mar 8. Dalton Trans. 2011. PMID: 21384047 Free PMC article.
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D. Ndengele MM, et al. Among authors: salvemini d. J Pharmacol Exp Ther. 2009 Apr;329(1):64-75. doi: 10.1124/jpet.108.146290. Epub 2008 Nov 25. J Pharmacol Exp Ther. 2009. PMID: 19033555 Free PMC article.
240 results