Hulme EC - Search Results

1

Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors.

Lebon G, Langmead CJ, Tehan BG, Hulme EC. Lebon G, et al. Among authors: hulme ec. Mol Pharmacol. 2009 Feb;75(2):331-41. doi: 10.1124/mol.108.050963. Epub 2008 Nov 11. Mol Pharmacol. 2009. PMID: 19001633 Free PMC article.

2

Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands.

Goodwin JA, Hulme EC, Langmead CJ, Tehan BG. Goodwin JA, et al. Among authors: hulme ec. Mol Pharmacol. 2007 Dec;72(6):1484-96. doi: 10.1124/mol.107.038265. Epub 2007 Sep 11. Mol Pharmacol. 2007. PMID: 17848601

3

Helix 8 of the M1 muscarinic acetylcholine receptor: scanning mutagenesis delineates a G protein recognition site.

Kaye RG, Saldanha JW, Lu ZL, Hulme EC. Kaye RG, et al. Among authors: hulme ec. Mol Pharmacol. 2011 Apr;79(4):701-9. doi: 10.1124/mol.110.070177. Epub 2011 Jan 19. Mol Pharmacol. 2011. PMID: 21247934 Free PMC article.

4

Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function.

Ward SD, Curtis CA, Hulme EC. Ward SD, et al. Among authors: hulme ec. Mol Pharmacol. 1999 Nov;56(5):1031-41. doi: 10.1124/mol.56.5.1031. Mol Pharmacol. 1999. PMID: 10531410

5

Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine.

Allman K, Page KM, Curtis CA, Hulme EC. Allman K, et al. Among authors: hulme ec. Mol Pharmacol. 2000 Jul;58(1):175-84. doi: 10.1124/mol.58.1.175. Mol Pharmacol. 2000. PMID: 10860940

6

The functional role of the binding site aspartate in muscarinic acetylcholine receptors, probed by site-directed mutagenesis.

Page KM, Curtis CA, Jones PG, Hulme EC. Page KM, et al. Among authors: hulme ec. Eur J Pharmacol. 1995 May 26;289(3):429-37. doi: 10.1016/0922-4106(95)90151-5. Eur J Pharmacol. 1995. PMID: 7556411

7

The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling.

Lu ZL, Curtis CA, Jones PG, Pavia J, Hulme EC. Lu ZL, et al. Among authors: hulme ec. Mol Pharmacol. 1997 Feb;51(2):234-41. doi: 10.1124/mol.51.2.234. Mol Pharmacol. 1997. PMID: 9203628

8

Functional analysis of transmembrane domain 2 of the M1 muscarinic acetylcholine receptor.

Bee MS, Hulme EC. Bee MS, et al. Among authors: hulme ec. J Biol Chem. 2007 Nov 2;282(44):32471-9. doi: 10.1074/jbc.M703909200. Epub 2007 Sep 6. J Biol Chem. 2007. PMID: 17823120 Free article.

9

The conformational switch in 7-transmembrane receptors: the muscarinic receptor paradigm.

Hulme EC, Lu ZL, Ward SD, Allman K, Curtis CA. Hulme EC, et al. Eur J Pharmacol. 1999 Jun 30;375(1-3):247-60. doi: 10.1016/s0014-2999(99)00297-6. Eur J Pharmacol. 1999. PMID: 10443581 Review.

10

Structure and activation of muscarinic acetylcholine receptors.

Hulme EC, Lu ZL, Saldanha JW, Bee MS. Hulme EC, et al. Biochem Soc Trans. 2003 Feb;31(Pt 1):29-34. doi: 10.1042/bst0310029. Biochem Soc Trans. 2003. PMID: 12546648 Review.

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