Langmead CJ - Search Results

1

Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors.

Lebon G, Langmead CJ, Tehan BG, Hulme EC. Lebon G, et al. Among authors: langmead cj. Mol Pharmacol. 2009 Feb;75(2):331-41. doi: 10.1124/mol.108.050963. Epub 2008 Nov 11. Mol Pharmacol. 2009. PMID: 19001633 Free PMC article.

2

Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist.

Langmead CJ, Fry VA, Forbes IT, Branch CL, Christopoulos A, Wood MD, Herdon HJ. Langmead CJ, et al. Mol Pharmacol. 2006 Jan;69(1):236-46. doi: 10.1124/mol.105.017814. Epub 2005 Oct 5. Mol Pharmacol. 2006. PMID: 16207821

3

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

May LT, Avlani VA, Langmead CJ, Herdon HJ, Wood MD, Sexton PM, Christopoulos A. May LT, et al. Among authors: langmead cj. Mol Pharmacol. 2007 Aug;72(2):463-76. doi: 10.1124/mol.107.037630. Epub 2007 May 24. Mol Pharmacol. 2007. PMID: 17525129

4

Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands.

Goodwin JA, Hulme EC, Langmead CJ, Tehan BG. Goodwin JA, et al. Among authors: langmead cj. Mol Pharmacol. 2007 Dec;72(6):1484-96. doi: 10.1124/mol.107.038265. Epub 2007 Sep 11. Mol Pharmacol. 2007. PMID: 17848601

5

Muscarinic acetylcholine receptors as CNS drug targets.

Langmead CJ, Watson J, Reavill C. Langmead CJ, et al. Pharmacol Ther. 2008 Feb;117(2):232-43. doi: 10.1016/j.pharmthera.2007.09.009. Epub 2007 Dec 20. Pharmacol Ther. 2008. PMID: 18082893 Review.

6

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1.

Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, Forbes IT, Fry VA, Hagan JJ, Herdon HJ, Jones GA, Jeggo R, Kew JN, Mazzali A, Melarange R, Patel N, Pardoe J, Randall AD, Roberts C, Roopun A, Starr KR, Teriakidis A, Wood MD, Whittington M, Wu Z, Watson J. Langmead CJ, et al. Br J Pharmacol. 2008 Jul;154(5):1104-15. doi: 10.1038/bjp.2008.152. Epub 2008 May 5. Br J Pharmacol. 2008. PMID: 18454168 Free PMC article.

7

G protein coupling and signaling pathway activation by m1 muscarinic acetylcholine receptor orthosteric and allosteric agonists.

Thomas RL, Mistry R, Langmead CJ, Wood MD, Challiss RA. Thomas RL, et al. Among authors: langmead cj. J Pharmacol Exp Ther. 2008 Nov;327(2):365-74. doi: 10.1124/jpet.108.141788. Epub 2008 Jul 29. J Pharmacol Exp Ther. 2008. PMID: 18664591 Free article.

8

Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.

Thomas RL, Langmead CJ, Wood MD, Challiss RA. Thomas RL, et al. Among authors: langmead cj. J Pharmacol Exp Ther. 2009 Dec;331(3):1086-95. doi: 10.1124/jpet.109.160242. Epub 2009 Sep 18. J Pharmacol Exp Ther. 2009. PMID: 19767446 Free PMC article.

9

Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor.

Avlani VA, Langmead CJ, Guida E, Wood MD, Tehan BG, Herdon HJ, Watson JM, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: langmead cj. Mol Pharmacol. 2010 Jul;78(1):94-104. doi: 10.1124/mol.110.064345. Epub 2010 Apr 22. Mol Pharmacol. 2010. PMID: 20413650

10

Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia.

Bradley SJ, Langmead CJ, Watson JM, Challiss RA. Bradley SJ, et al. Among authors: langmead cj. Mol Pharmacol. 2011 May;79(5):874-85. doi: 10.1124/mol.110.068882. Epub 2011 Feb 14. Mol Pharmacol. 2011. PMID: 21321061 Free PMC article.

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