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Page 1
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.
Chen C, Wu D, Guo Z, Xie Q, Reinhart GJ, Madan A, Wen J, Chen T, Huang CQ, Chen M, Chen Y, Tucci FC, Rowbottom M, Pontillo J, Zhu YF, Wade W, Saunders J, Bozigian H, Struthers RS. Chen C, et al. Among authors: wen j. J Med Chem. 2008 Dec 11;51(23):7478-85. doi: 10.1021/jm8006454. J Med Chem. 2008. PMID: 19006286
Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.
Jiang W, Tucci FC, Chen CW, Arellano M, Tran JA, White NS, Marinkovic D, Pontillo J, Fleck BA, Wen J, Saunders J, Madan A, Foster AC, Chen C. Jiang W, et al. Among authors: wen j. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4674-8. doi: 10.1016/j.bmcl.2006.05.088. Epub 2006 Jun 13. Bioorg Med Chem Lett. 2006. PMID: 16777413
Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.
Hudson S, Kiankarimi M, Rowbottom MW, Vickers TD, Wu D, Pontillo J, Ching B, Dwight W, Goodfellow VS, Schwarz D, Heise CE, Madan A, Wen J, Ban W, Wang H, Wade WS. Hudson S, et al. Among authors: wen j. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4922-30. doi: 10.1016/j.bmcl.2006.06.049. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824755
Propionylpiperazines as human melanocortin-4 receptor ligands.
Chen CW, Tran JA, Jiang W, Tucci FC, Arellano M, Wen J, Fleck BA, Marinkovic D, White NS, Pontillo J, Saunders J, Madan A, Foster AC, Chen C. Chen CW, et al. Among authors: wen j. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4800-3. doi: 10.1016/j.bmcl.2006.06.075. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824757
Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.
Chen M, Guo Z, Lanier MC, Zhao L, Betz SF, Huang CQ, Loweth CJ, Ashweek NJ, Liu XJ, Struthers RS, Bradbury MJ, Behan JW, Wen J, O'Brien Z, Saunders J, Zhu YF. Chen M, et al. Among authors: wen j. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3845-50. doi: 10.1016/j.bmcl.2007.05.009. Epub 2007 May 10. Bioorg Med Chem Lett. 2007. PMID: 17521908
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.
Tran JA, Tucci FC, Jiang W, Marinkovic D, Chen CW, Arellano M, Markison S, Fleck BA, Wen J, White NS, Pontillo J, Saunders J, Marks D, Hoare SR, Madan A, Foster AC, Chen C. Tran JA, et al. Among authors: wen j. Bioorg Med Chem. 2007 Aug 1;15(15):5166-76. doi: 10.1016/j.bmc.2007.05.026. Epub 2007 May 17. Bioorg Med Chem. 2007. PMID: 17544282
9,368 results