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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.
Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. Schröder R, et al. Among authors: pardo l. J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19010788 Free article.
A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.
Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E. Blättermann S, et al. Among authors: pardo l. Nat Chem Biol. 2012 Jul;8(7):631-8. doi: 10.1038/nchembio.962. Epub 2012 May 27. Nat Chem Biol. 2012. PMID: 22634634
Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding.
Verzijl D, Pardo L, van Dijk M, Gruijthuijsen YK, Jongejan A, Timmerman H, Nicholas J, Schwarz M, Murphy PM, Leurs R, Smit MJ. Verzijl D, et al. Among authors: pardo l. J Biol Chem. 2006 Nov 17;281(46):35327-35. doi: 10.1074/jbc.M606877200. Epub 2006 Sep 22. J Biol Chem. 2006. PMID: 16997914 Free article.
Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers.
Navarro G, Ferré S, Cordomi A, Moreno E, Mallol J, Casadó V, Cortés A, Hoffmann H, Ortiz J, Canela EI, Lluís C, Pardo L, Franco R, Woods AS. Navarro G, et al. Among authors: pardo l. J Biol Chem. 2010 Aug 27;285(35):27346-27359. doi: 10.1074/jbc.M110.115634. Epub 2010 Jun 18. J Biol Chem. 2010. PMID: 20562103 Free PMC article.
603 results