Arndt K - Search Results

1

IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model.

Zhang Y, Gavriil M, Lucas J, Mandiyan S, Follettie M, Diesl V, Sum FW, Powell D, Haney S, Abraham R, Arndt K. Zhang Y, et al. Among authors: arndt k. Cancer Res. 2008 Nov 15;68(22):9519-24. doi: 10.1158/0008-5472.CAN-08-1549. Cancer Res. 2008. PMID: 19010928

2

SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.

Golas JM, Lucas J, Etienne C, Golas J, Discafani C, Sridharan L, Boghaert E, Arndt K, Ye F, Boschelli DH, Li F, Titsch C, Huselton C, Chaudhary I, Boschelli F. Golas JM, et al. Among authors: arndt k. Cancer Res. 2005 Jun 15;65(12):5358-64. doi: 10.1158/0008-5472.CAN-04-2484. Cancer Res. 2005. PMID: 15958584

3

Specific IKKbeta inhibitor IV blocks Streptonigrin-induced NF-kappaB activity and potentiates its cytotoxic effect on cancer cells.

Gavriil M, Tsao CC, Mandiyan S, Arndt K, Abraham R, Zhang Y. Gavriil M, et al. Among authors: arndt k. Mol Carcinog. 2009 Aug;48(8):678-84. doi: 10.1002/mc.20550. Mol Carcinog. 2009. PMID: 19444813

4

Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.

Loganzo F, Tan X, Sung M, Jin G, Myers JS, Melamud E, Wang F, Diesl V, Follettie MT, Musto S, Lam MH, Hu W, Charati MB, Khandke K, Kim KS, Cinque M, Lucas J, Graziani E, Maderna A, O'Donnell CJ, Arndt KT, Gerber HP. Loganzo F, et al. Among authors: arndt kt. Mol Cancer Ther. 2015 Apr;14(4):952-63. doi: 10.1158/1535-7163.MCT-14-0862. Epub 2015 Feb 2. Mol Cancer Ther. 2015. PMID: 25646013

5

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment.

VanArsdale T, Boshoff C, Arndt KT, Abraham RT. VanArsdale T, et al. Clin Cancer Res. 2015 Jul 1;21(13):2905-10. doi: 10.1158/1078-0432.CCR-14-0816. Epub 2015 May 4. Clin Cancer Res. 2015. PMID: 25941111 Review.

6

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, Frost P, Ye F, Boschelli DH, Boschelli F. Golas JM, et al. Among authors: arndt k. Cancer Res. 2003 Jan 15;63(2):375-81. Cancer Res. 2003. PMID: 12543790

7

Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition.

Dehnhardt CM, Venkatesan AM, Chen Z, Ayral-Kaloustian S, Dos Santos O, Delos Santos E, Curran K, Follettie MT, Diesl V, Lucas J, Geng Y, Dejoy SQ, Petersen R, Chaudhary I, Brooijmans N, Mansour TS, Arndt K, Chen L. Dehnhardt CM, et al. Among authors: arndt k. J Med Chem. 2010 Jan 28;53(2):897-910. doi: 10.1021/jm901370m. J Med Chem. 2010. PMID: 20025292

8

Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKbeta inhibitors.

Crombie AL, Sum FW, Powell DW, Hopper DW, Torres N, Berger DM, Zhang Y, Gavriil M, Sadler TM, Arndt K. Crombie AL, et al. Among authors: arndt k. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3821-5. doi: 10.1016/j.bmcl.2010.04.022. Epub 2010 Apr 18. Bioorg Med Chem Lett. 2010. PMID: 20471256

9

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.

Boschelli DH, Ye F, Wang YD, Dutia M, Johnson SL, Wu B, Miller K, Powell DW, Yaczko D, Young M, Tischler M, Arndt K, Discafani C, Etienne C, Gibbons J, Grod J, Lucas J, Weber JM, Boschelli F. Boschelli DH, et al. Among authors: arndt k. J Med Chem. 2001 Nov 8;44(23):3965-77. doi: 10.1021/jm0102250. J Med Chem. 2001. PMID: 11689083

10

2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer.

Chen Z, Venkatesan AM, Dehnhardt CM, Dos Santos O, Delos Santos E, Ayral-Kaloustian S, Chen L, Geng Y, Arndt KT, Lucas J, Chaudhary I, Mansour TS. Chen Z, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4980-3. doi: 10.1016/j.bmcl.2009.07.070. Epub 2009 Jul 17. Bioorg Med Chem Lett. 2009. PMID: 19640711

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