Winton DJ - Search Results

1

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR. Marsh V, et al. Among authors: winton dj. Nat Genet. 2008 Dec;40(12):1436-44. doi: 10.1038/ng.256. Epub 2008 Nov 16. Nat Genet. 2008. PMID: 19011632

2

p53, mutation frequency and apoptosis in the murine small intestine.

Clarke AR, Howard LA, Harrison DJ, Winton DJ. Clarke AR, et al. Among authors: winton dj. Oncogene. 1997 May 1;14(17):2015-8. doi: 10.1038/sj.onc.1201040. Oncogene. 1997. PMID: 9160880

3

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine.

Toft NJ, Winton DJ, Kelly J, Howard LA, Dekker M, te Riele H, Arends MJ, Wyllie AH, Margison GP, Clarke AR. Toft NJ, et al. Among authors: winton dj. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3911-5. doi: 10.1073/pnas.96.7.3911. Proc Natl Acad Sci U S A. 1999. PMID: 10097137 Free PMC article.

4

In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.

Toft NJ, Sansom OJ, Brookes RA, Arends MJ, Wood M, Margison GP, Winton DJ, Clarke AR. Toft NJ, et al. Among authors: winton dj. Carcinogenesis. 2000 Apr;21(4):593-8. doi: 10.1093/carcin/21.4.593. Carcinogenesis. 2000. PMID: 10753191

5

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner.

Sansom OJ, Toft NJ, Winton DJ, Clarke AR. Sansom OJ, et al. Among authors: winton dj. Oncogene. 2001 Jun 14;20(27):3580-4. doi: 10.1038/sj.onc.1204449. Oncogene. 2001. PMID: 11429706

6

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.

Ireland H, Kemp R, Houghton C, Howard L, Clarke AR, Sansom OJ, Winton DJ. Ireland H, et al. Among authors: winton dj. Gastroenterology. 2004 May;126(5):1236-46. doi: 10.1053/j.gastro.2004.03.020. Gastroenterology. 2004. PMID: 15131783

7

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ. Sansom OJ, et al. Among authors: winton dj. Genes Dev. 2004 Jun 15;18(12):1385-90. doi: 10.1101/gad.287404. Genes Dev. 2004. PMID: 15198980 Free PMC article.

8

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.

Reed KR, Sansom OJ, Hayes AJ, Gescher AJ, Winton DJ, Peters JM, Clarke AR. Reed KR, et al. Among authors: winton dj. Oncogene. 2004 Nov 25;23(55):8992-6. doi: 10.1038/sj.onc.1208143. Oncogene. 2004. PMID: 15480419

9

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.

Hay T, Patrick T, Winton D, Sansom OJ, Clarke AR. Hay T, et al. Oncogene. 2005 May 26;24(23):3842-6. doi: 10.1038/sj.onc.1208533. Oncogene. 2005. PMID: 15735671

10

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

Sansom OJ, Reed KR, van de Wetering M, Muncan V, Winton DJ, Clevers H, Clarke AR. Sansom OJ, et al. Among authors: winton dj. J Biol Chem. 2005 Aug 5;280(31):28463-7. doi: 10.1074/jbc.M500191200. Epub 2005 Jun 9. J Biol Chem. 2005. PMID: 15946945 Free article.

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