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Page 1
A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects.
Hecht I, Rong J, Sampaio AL, Hermesh C, Rutledge C, Shemesh R, Toporik A, Beiman M, Dassa L, Niv H, Cojocaru G, Zauberman A, Rotman G, Perretti M, Vinten-Johansen J, Cohen Y. Hecht I, et al. Among authors: toporik a. J Pharmacol Exp Ther. 2009 Feb;328(2):426-34. doi: 10.1124/jpet.108.145821. Epub 2008 Nov 20. J Pharmacol Exp Ther. 2009. PMID: 19023040
Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.
David A, Mabjeesh N, Azar I, Biton S, Engel S, Bernstein J, Romano J, Avidor Y, Waks T, Eshhar Z, Langer SZ, Lifschitz-Mercer B, Matzkin H, Rotman G, Toporik A, Savitsky K, Mintz L. David A, et al. Among authors: toporik a. J Biol Chem. 2002 May 17;277(20):18084-90. doi: 10.1074/jbc.M102285200. Epub 2002 Feb 7. J Biol Chem. 2002. PMID: 11834722 Free article.
Transcription-mediated gene fusion in the human genome.
Akiva P, Toporik A, Edelheit S, Peretz Y, Diber A, Shemesh R, Novik A, Sorek R. Akiva P, et al. Among authors: toporik a. Genome Res. 2006 Jan;16(1):30-6. doi: 10.1101/gr.4137606. Epub 2005 Dec 12. Genome Res. 2006. PMID: 16344562 Free PMC article.
Discovery and validation of novel peptide agonists for G-protein-coupled receptors.
Shemesh R, Toporik A, Levine Z, Hecht I, Rotman G, Wool A, Dahary D, Gofer E, Kliger Y, Soffer MA, Rosenberg A, Eshel D, Cohen Y. Shemesh R, et al. Among authors: toporik a. J Biol Chem. 2008 Dec 12;283(50):34643-9. doi: 10.1074/jbc.M805181200. Epub 2008 Oct 9. J Biol Chem. 2008. PMID: 18854305 Free PMC article.
Peptides modulating conformational changes in secreted chaperones: from in silico design to preclinical proof of concept.
Kliger Y, Levy O, Oren A, Ashkenazy H, Tiran Z, Novik A, Rosenberg A, Amir A, Wool A, Toporik A, Schreiber E, Eshel D, Levine Z, Cohen Y, Nold-Petry C, Dinarello CA, Borukhov I. Kliger Y, et al. Among authors: toporik a. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13797-801. doi: 10.1073/pnas.0906514106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666568 Free PMC article.
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Hecht I, Toporik A, Podojil JR, Vaknin I, Cojocaru G, Oren A, Aizman E, Liang SC, Leung L, Dicken Y, Novik A, Marbach-Bar N, Elmesmari A, Tange C, Gilmour A, McIntyre D, Kurowska-Stolarska M, McNamee K, Leitner J, Greenwald S, Dassa L, Levine Z, Steinberger P, Williams RO, Miller SD, McInnes IB, Neria E, Rotman G. Hecht I, et al. Among authors: toporik a. J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325. Epub 2018 Feb 5. J Immunol. 2018. PMID: 29431694 Free PMC article.
Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.
Menachem A, Alteber Z, Cojocaru G, Fridman Kfir T, Blat D, Leiderman O, Galperin M, Sever L, Cohen N, Cohen K, Granit RZ, Vols S, Frenkel M, Soffer L, Meyer K, Menachem K, Galon Tilleman H, Morein D, Borukhov I, Toporik A, Perpinial Shahor M, Tatirovsky E, Mizrachi A, Levy-Barda A, Sadot E, Strenov Y, Eitan R, Jakobson-Setton A, Yanichkin N, Ferre P, Ophir E. Menachem A, et al. Among authors: toporik a. Cancer Immunol Res. 2024 Jun 4;12(6):687-703. doi: 10.1158/2326-6066.CIR-23-0706. Cancer Immunol Res. 2024. PMID: 38592331 Free PMC article.
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.
Stanietsky N, Simic H, Arapovic J, Toporik A, Levy O, Novik A, Levine Z, Beiman M, Dassa L, Achdout H, Stern-Ginossar N, Tsukerman P, Jonjic S, Mandelboim O. Stanietsky N, et al. Among authors: toporik a. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17858-63. doi: 10.1073/pnas.0903474106. Epub 2009 Oct 7. Proc Natl Acad Sci U S A. 2009. PMID: 19815499 Free PMC article.
14 results