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Characterization of novel glutathione adducts of a non-nucleoside reverse transcriptase inhibitor, (S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3, 4-dihydro-2(1H)-quinazolinone (DPC 961), in rats. Possible formation of an oxirene metabolic intermediate from a disubstituted alkyne.
Mutlib A, Chen H, Shockcor J, Espina R, Chen S, Cao K, Du A, Nemeth G, Prakash S, Gan LS. Mutlib A, et al. Among authors: du a. Chem Res Toxicol. 2000 Aug;13(8):775-84. doi: 10.1021/tx000029g. Chem Res Toxicol. 2000. PMID: 10956066
China Bioanalysis Forum.
Tang D, Zhong D, Dong K, Hu P, Liu H, Jiang H, Du A. Tang D, et al. Among authors: du a. Bioanalysis. 2013 Mar;5(6):641-3. doi: 10.4155/bio.13.24. Bioanalysis. 2013. PMID: 23484782 No abstract available.
971 results