Hubbard A - Search Results

1

Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B.

Braiterman L, Nyasae L, Guo Y, Bustos R, Lutsenko S, Hubbard A. Braiterman L, et al. Among authors: hubbard a. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G433-44. doi: 10.1152/ajpgi.90489.2008. Epub 2008 Nov 25. Am J Physiol Gastrointest Liver Physiol. 2009. PMID: 19033537 Free PMC article.

2

Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites.

Nyasae L, Bustos R, Braiterman L, Eipper B, Hubbard A. Nyasae L, et al. Among authors: hubbard a. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1181-94. doi: 10.1152/ajpgi.00472.2006. Epub 2006 Dec 7. Am J Physiol Gastrointest Liver Physiol. 2007. PMID: 17158254 Free article.

3

Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein.

Gupta A, Bhattacharjee A, Dmitriev OY, Nokhrin S, Braiterman L, Hubbard AL, Lutsenko S. Gupta A, et al. Among authors: hubbard al. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5390-5. doi: 10.1073/pnas.1014959108. Epub 2011 Mar 15. Proc Natl Acad Sci U S A. 2011. PMID: 21406592 Free PMC article.

4

Distinct phenotype of a Wilson disease mutation reveals a novel trafficking determinant in the copper transporter ATP7B.

Braiterman LT, Murthy A, Jayakanthan S, Nyasae L, Tzeng E, Gromadzka G, Woolf TB, Lutsenko S, Hubbard AL. Braiterman LT, et al. Among authors: hubbard al. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1364-73. doi: 10.1073/pnas.1314161111. Epub 2014 Mar 24. Proc Natl Acad Sci U S A. 2014. PMID: 24706876 Free PMC article.

5

Copper directs ATP7B to the apical domain of hepatic cells via basolateral endosomes.

Nyasae LK, Schell MJ, Hubbard AL. Nyasae LK, et al. Traffic. 2014 Dec;15(12):1344-65. doi: 10.1111/tra.12229. Epub 2014 Oct 27. Traffic. 2014. PMID: 25243755 Free PMC article.

6

Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).

Braiterman LT, Gupta A, Chaerkady R, Cole RN, Hubbard AL. Braiterman LT, et al. Among authors: hubbard al. J Biol Chem. 2015 Apr 3;290(14):8803-19. doi: 10.1074/jbc.M114.627414. Epub 2015 Feb 9. J Biol Chem. 2015. PMID: 25666620 Free PMC article.

7

NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells.

Guo Y, Nyasae L, Braiterman LT, Hubbard AL. Guo Y, et al. Among authors: hubbard al. Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G904-16. doi: 10.1152/ajpgi.00262.2005. Epub 2005 Jun 30. Am J Physiol Gastrointest Liver Physiol. 2005. PMID: 15994426 Free article.

8

Critical roles for the COOH terminus of the Cu-ATPase ATP7B in protein stability, trans-Golgi network retention, copper sensing, and retrograde trafficking.

Braiterman L, Nyasae L, Leves F, Hubbard AL. Braiterman L, et al. Among authors: hubbard al. Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G69-81. doi: 10.1152/ajpgi.00038.2011. Epub 2011 Mar 31. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21454443 Free PMC article.

9

Nonpolarized cells selectively sort apical proteins from cell surface to a novel compartment, but lack apical retention mechanisms.

Tuma PL, Nyasae LK, Hubbard AL. Tuma PL, et al. Mol Biol Cell. 2002 Oct;13(10):3400-15. doi: 10.1091/mbc.02-04-0054. Mol Biol Cell. 2002. PMID: 12388745 Free PMC article.

10

Transcytotic efflux from early endosomes is dependent on cholesterol and glycosphingolipids in polarized hepatic cells.

Nyasae LK, Hubbard AL, Tuma PL. Nyasae LK, et al. Mol Biol Cell. 2003 Jul;14(7):2689-705. doi: 10.1091/mbc.e02-12-0816. Epub 2003 Apr 4. Mol Biol Cell. 2003. PMID: 12857857 Free PMC article.

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