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Induction of endothelial nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells.
Hisamoto K, Ohmichi M, Kanda Y, Adachi K, Nishio Y, Hayakawa J, Mabuchi S, Takahashi K, Tasaka K, Miyamoto Y, Taniguchi N, Murata Y. Hisamoto K, et al. Among authors: mabuchi s. J Biol Chem. 2001 Dec 14;276(50):47642-9. doi: 10.1074/jbc.M103853200. Epub 2001 Oct 10. J Biol Chem. 2001. PMID: 11595733 Free article.
Both estrogen and raloxifene cause G1 arrest of vascular smooth muscle cells.
Takahashi K, Ohmichi M, Yoshida M, Hisamoto K, Mabuchi S, Arimoto-Ishida E, Mori A, Tsutsumi S, Tasaka K, Murata Y, Kurachi H. Takahashi K, et al. Among authors: mabuchi s. J Endocrinol. 2003 Aug;178(2):319-29. doi: 10.1677/joe.0.1780319. J Endocrinol. 2003. PMID: 12904179
Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin.
Mabuchi S, Ohmichi M, Kimura A, Ikebuchi Y, Hisamoto K, Arimoto-Ishida E, Nishio Y, Takahashi K, Tasaka K, Murata Y. Mabuchi S, et al. Endocrinology. 2004 Mar;145(3):1302-13. doi: 10.1210/en.2003-0709. Epub 2003 Nov 26. Endocrinology. 2004. PMID: 14645110
286 results