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A peptide prodrug approach for improving bisphosphonate oral absorption.
Ezra A, Hoffman A, Breuer E, Alferiev IS, Mönkkönen J, El Hanany-Rozen N, Weiss G, Stepensky D, Gati I, Cohen H, Törmälehto S, Amidon GL, Golomb G. Ezra A, et al. Among authors: hoffman a. J Med Chem. 2000 Oct 5;43(20):3641-52. doi: 10.1021/jm980645y. J Med Chem. 2000. PMID: 11020278
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.
Hess S, Linde Y, Ovadia O, Safrai E, Shalev DE, Swed A, Halbfinger E, Lapidot T, Winkler I, Gabinet Y, Faier A, Yarden D, Xiang Z, Portillo FP, Haskell-Luevano C, Gilon C, Hoffman A. Hess S, et al. Among authors: hoffman a. J Med Chem. 2008 Feb 28;51(4):1026-34. doi: 10.1021/jm701093y. Epub 2008 Jan 26. J Med Chem. 2008. PMID: 18220330
Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor--synthesis and pharmacodynamic and pharmacokinetic analysis.
Hoffman A, Qadri B, Frant J, Katz Y, Bhusare SR, Breuer E, Hadar R, Reich R. Hoffman A, et al. J Med Chem. 2008 Mar 13;51(5):1406-14. doi: 10.1021/jm701087n. Epub 2008 Feb 8. J Med Chem. 2008. PMID: 18257543
Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: the HIV-1 CD4:gp120 paradigm.
Hurevich M, Swed A, Joubran S, Cohen S, Freeman NS, Britan-Rosich E, Briant-Longuet L, Bardy M, Devaux C, Kotler M, Hoffman A, Gilon C. Hurevich M, et al. Among authors: hoffman a. Bioorg Med Chem. 2010 Aug 1;18(15):5754-61. doi: 10.1016/j.bmc.2010.04.053. Epub 2010 Apr 21. Bioorg Med Chem. 2010. PMID: 20619663
2,382 results