Thoma G - Search Results

1

Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.

Thoma G, Streiff MB, Kovarik J, Glickman F, Wagner T, Beerli C, Zerwes HG. Thoma G, et al. J Med Chem. 2008 Dec 25;51(24):7915-20. doi: 10.1021/jm801065q. J Med Chem. 2008. PMID: 19053768

2

Synthesis and biological evaluation of a potent E-selectin antagonist.

Thoma G, Kinzy W, Bruns C, Patton JT, Magnani JL, Bänteli R. Thoma G, et al. J Med Chem. 1999 Nov 18;42(23):4909-13. doi: 10.1021/jm990422n. J Med Chem. 1999. PMID: 10579852

3

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.

Thoma G, Magnani JL, Patton JT. Thoma G, et al. Bioorg Med Chem Lett. 2001 Apr 9;11(7):923-5. doi: 10.1016/s0960-894x(01)00092-0. Bioorg Med Chem Lett. 2001. PMID: 11294392

4

Novel glycodendrimers self-assemble to nanoparticles which function as polyvalent ligands in vitro and in vivo.

Thoma G, Katopodis AG, Voelcker N, Duthaler RO, Streiff MB. Thoma G, et al. Angew Chem Int Ed Engl. 2002 Sep 2;41(17):3195-8. doi: 10.1002/1521-3773(20020902)41:17<3195::AID-ANIE3195>3.0.CO;2-X. Angew Chem Int Ed Engl. 2002. PMID: 12207387 No abstract available.

5

Removal of anti-Galalpha1,3Gal xenoantibodies with an injectable polymer.

Katopodis AG, Warner RG, Duthaler RO, Streiff MB, Bruelisauer A, Kretz O, Dorobek B, Persohn E, Andres H, Schweitzer A, Thoma G, Kinzy W, Quesniaux VF, Cozzi E, Davies HF, Mañez R, White D. Katopodis AG, et al. Among authors: thoma g. J Clin Invest. 2002 Dec;110(12):1869-77. doi: 10.1172/JCI16526. J Clin Invest. 2002. PMID: 12488437 Free PMC article.

6

Orally bioavailable competitive CCR5 antagonists.

Thoma G, Nuninger F, Schaefer M, Akyel KG, Albert R, Beerli C, Bruns C, Francotte E, Luyten M, MacKenzie D, Oberer L, Streiff MB, Wagner T, Walter H, Weckbecker G, Zerwes HG. Thoma G, et al. J Med Chem. 2004 Apr 8;47(8):1939-55. doi: 10.1021/jm031046g. J Med Chem. 2004. PMID: 15055994

7

Non-covalent polyvalent ligands by self-assembly of small glycodendrimers: a novel concept for the inhibition of polyvalent carbohydrate-protein interactions in vitro and in vivo.

Thoma G, Streiff MB, Katopodis AG, Duthaler RO, Voelcker NH, Ehrhardt C, Masson C. Thoma G, et al. Chemistry. 2005 Dec 16;12(1):99-117. doi: 10.1002/chem.200500901. Chemistry. 2005. PMID: 16231293

8

Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo.

Thoma G, Beerli C, Bigaud M, Bruns C, Cooke NG, Streiff MB, Zerwes HG. Thoma G, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2000-5. doi: 10.1016/j.bmcl.2008.01.108. Epub 2008 Feb 2. Bioorg Med Chem Lett. 2008. PMID: 18267361

9

The chemokine receptor Cxcr3 is not essential for acute cardiac allograft rejection in mice and rats.

Zerwes HG, Li J, Kovarik J, Streiff M, Hofmann M, Roth L, Luyten M, Pally C, Loewe RP, Wieczorek G, Bänteli R, Thoma G, Luckow B. Zerwes HG, et al. Among authors: thoma g. Am J Transplant. 2008 Aug;8(8):1604-13. doi: 10.1111/j.1600-6143.2008.02309.x. Epub 2008 Jun 28. Am J Transplant. 2008. PMID: 18557719 Free article.

10

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.

Thoma G, Baenteli R, Lewis I, Wagner T, Oberer L, Blum W, Glickman F, Streiff MB, Zerwes HG. Thoma G, et al. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6185-8. doi: 10.1016/j.bmcl.2009.09.002. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19783143

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