Gunaratnam M - Search Results

1

Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.

Drewe WC, Nanjunda R, Gunaratnam M, Beltran M, Parkinson GN, Reszka AP, Wilson WD, Neidle S. Drewe WC, et al. Among authors: gunaratnam m. J Med Chem. 2008 Dec 25;51(24):7751-67. doi: 10.1021/jm801245v. J Med Chem. 2008. PMID: 19053833 Free PMC article.

2

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Moore MJ, Schultes CM, Cuesta J, Cuenca F, Gunaratnam M, Tanious FA, Wilson WD, Neidle S. Moore MJ, et al. Among authors: gunaratnam m. J Med Chem. 2006 Jan 26;49(2):582-99. doi: 10.1021/jm050555a. J Med Chem. 2006. PMID: 16420044

3

Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.

Martins C, Gunaratnam M, Stuart J, Makwana V, Greciano O, Reszka AP, Kelland LR, Neidle S. Martins C, et al. Among authors: gunaratnam m. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2293-8. doi: 10.1016/j.bmcl.2007.01.056. Epub 2007 Jan 25. Bioorg Med Chem Lett. 2007. PMID: 17276687

4

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

Cuenca F, Greciano O, Gunaratnam M, Haider S, Munnur D, Nanjunda R, Wilson WD, Neidle S. Cuenca F, et al. Among authors: gunaratnam m. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1668-73. doi: 10.1016/j.bmcl.2008.01.050. Epub 2008 Jan 18. Bioorg Med Chem Lett. 2008. PMID: 18243701

5

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

Gunaratnam M, Swank S, Haider SM, Galesa K, Reszka AP, Beltran M, Cuenca F, Fletcher JA, Neidle S. Gunaratnam M, et al. J Med Chem. 2009 Jun 25;52(12):3774-83. doi: 10.1021/jm900424a. J Med Chem. 2009. PMID: 19469547 Free PMC article.

6

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

Rahman KM, Reszka AP, Gunaratnam M, Haider SM, Howard PW, Fox KR, Neidle S, Thurston DE. Rahman KM, et al. Among authors: gunaratnam m. Chem Commun (Camb). 2009 Jul 21;(27):4097-9. doi: 10.1039/b902359c. Epub 2009 Jun 5. Chem Commun (Camb). 2009. PMID: 19568645

7

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells.

Gunaratnam M, Neidle S. Gunaratnam M, et al. Methods Mol Biol. 2010;613:303-13. doi: 10.1007/978-1-60327-418-0_19. Methods Mol Biol. 2010. PMID: 19997892

8

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.

Hampel SM, Sidibe A, Gunaratnam M, Riou JF, Neidle S. Hampel SM, et al. Among authors: gunaratnam m. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6459-63. doi: 10.1016/j.bmcl.2010.09.066. Epub 2010 Sep 17. Bioorg Med Chem Lett. 2010. PMID: 20932753

9

Targeting pancreatic cancer with a G-quadruplex ligand.

Gunaratnam M, de la Fuente M, Hampel SM, Todd AK, Reszka AP, Schätzlein A, Neidle S. Gunaratnam M, et al. Bioorg Med Chem. 2011 Dec 1;19(23):7151-7. doi: 10.1016/j.bmc.2011.09.055. Epub 2011 Oct 10. Bioorg Med Chem. 2011. PMID: 22041170

10

Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes.

Campbell NH, Karim NH, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S. Campbell NH, et al. Among authors: gunaratnam m. J Med Chem. 2012 Jan 12;55(1):209-22. doi: 10.1021/jm201140v. Epub 2011 Dec 13. J Med Chem. 2012. PMID: 22112241

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