Lowe ED - Search Results

1

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.

Russell AJ, Westwood IM, Crawford MH, Robinson J, Kawamura A, Redfield C, Laurieri N, Lowe ED, Davies SG, Sim E. Russell AJ, et al. Among authors: lowe ed. Bioorg Med Chem. 2009 Jan 15;17(2):905-18. doi: 10.1016/j.bmc.2008.11.032. Epub 2008 Nov 19. Bioorg Med Chem. 2009. PMID: 19059786

2

Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa.

Wang CJ, Hagemeier C, Rahman N, Lowe E, Noble M, Coughtrie M, Sim E, Westwood I. Wang CJ, et al. J Mol Biol. 2007 Nov 9;373(5):1213-28. doi: 10.1016/j.jmb.2007.08.048. Epub 2007 Aug 25. J Mol Biol. 2007. PMID: 17904577

3

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase.

Fullam E, Westwood IM, Anderton MC, Lowe ED, Sim E, Noble ME. Fullam E, et al. Among authors: lowe ed. J Mol Biol. 2008 Jan 4;375(1):178-91. doi: 10.1016/j.jmb.2007.10.019. Epub 2007 Oct 13. J Mol Biol. 2008. PMID: 18005984

4

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis.

Lack N, Lowe ED, Liu J, Eltis LD, Noble ME, Sim E, Westwood IM. Lack N, et al. Among authors: lowe ed. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt 1):2-7. doi: 10.1107/S1744309107065931. Epub 2007 Dec 20. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18097091 Free PMC article.

5

Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase.

Lowe ED, Gao GY, Johnson LN, Keung WM. Lowe ED, et al. J Med Chem. 2008 Aug 14;51(15):4482-7. doi: 10.1021/jm800488j. Epub 2008 Jul 10. J Med Chem. 2008. PMID: 18613661

6

Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins.

Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA. Jensen SA, et al. Among authors: lowe ed. Structure. 2009 May 13;17(5):759-68. doi: 10.1016/j.str.2009.03.014. Structure. 2009. PMID: 19446531 Free PMC article.

7

Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.

Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD. Lack NA, et al. Among authors: lowe ed. J Biol Chem. 2010 Jan 1;285(1):434-43. doi: 10.1074/jbc.M109.058081. Epub 2009 Oct 29. J Biol Chem. 2010. PMID: 19875455 Free PMC article.

8

Role of tyrosine 131 in the active site of paAzoR1, an azoreductase with specificity for the inflammatory bowel disease prodrug balsalazide.

Wang CJ, Laurieri N, Abuhammad A, Lowe E, Westwood I, Ryan A, Sim E. Wang CJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 1;66(Pt 1):2-7. doi: 10.1107/S1744309109044741. Epub 2009 Dec 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20057057 Free PMC article.

9

A novel mechanism for azoreduction.

Ryan A, Laurieri N, Westwood I, Wang CJ, Lowe E, Sim E. Ryan A, et al. J Mol Biol. 2010 Jul 2;400(1):24-37. doi: 10.1016/j.jmb.2010.04.023. Epub 2010 Apr 24. J Mol Biol. 2010. PMID: 20417637

10

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.

Abuhammad AM, Lowe ED, Fullam E, Noble M, Garman EF, Sim E. Abuhammad AM, et al. Among authors: lowe ed. Protein Cell. 2010 Apr;1(4):384-392. doi: 10.1007/s13238-010-0037-7. Epub 2010 May 8. Protein Cell. 2010. PMID: 21203950 Free PMC article.

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