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Page 1
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. Monk BC, et al. Among authors: o connell jd 3rd. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi: 10.1073/pnas.1324245111. Epub 2014 Feb 3. Proc Natl Acad Sci U S A. 2014. PMID: 24613931 Free PMC article.
Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter.
Pak JE, Ekendé EN, Kifle EG, O'Connell JD 3rd, De Angelis F, Tessema MB, Derfoufi KM, Robles-Colmenares Y, Robbins RA, Goormaghtigh E, Vandenbussche G, Stroud RM. Pak JE, et al. Among authors: o connell jd 3rd. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18484-9. doi: 10.1073/pnas.1318705110. Epub 2013 Oct 30. Proc Natl Acad Sci U S A. 2013. PMID: 24173033 Free PMC article.
Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
Tochowicz A, Dalziel S, Eidam O, O'Connell JD 3rd, Griner S, Finer-Moore JS, Stroud RM. Tochowicz A, et al. Among authors: o connell jd 3rd. J Med Chem. 2013 Jul 11;56(13):5446-55. doi: 10.1021/jm400490e. Epub 2013 Jun 21. J Med Chem. 2013. PMID: 23710599 Free PMC article.
Structural context shapes the aquaporin selectivity filter.
Savage DF, O'Connell JD 3rd, Miercke LJ, Finer-Moore J, Stroud RM. Savage DF, et al. Among authors: o connell jd 3rd. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17164-9. doi: 10.1073/pnas.1009864107. Epub 2010 Sep 20. Proc Natl Acad Sci U S A. 2010. PMID: 20855585 Free PMC article.
Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems.
De Angelis F, Lee JK, O'Connell JD 3rd, Miercke LJ, Verschueren KH, Srinivasan V, Bauvois C, Govaerts C, Robbins RA, Ruysschaert JM, Stroud RM, Vandenbussche G. De Angelis F, et al. Among authors: o connell jd 3rd. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11038-43. doi: 10.1073/pnas.1003908107. Epub 2010 Jun 1. Proc Natl Acad Sci U S A. 2010. PMID: 20534468 Free PMC article.