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The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, Sidhu AB, Purcell LA, Gratraud P, Kremer L, Waters AP, Schiehser G, Jacobus DP, Janse CJ, Ager A, Jacobs WR Jr, Sacchettini JC, Heussler V, Sinnis P, Fidock DA. Yu M, et al. Among authors: heussler v. Cell Host Microbe. 2008 Dec 11;4(6):567-78. doi: 10.1016/j.chom.2008.11.001. Cell Host Microbe. 2008. PMID: 19064257 Free PMC article.
Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.
van Dijk MR, Douradinha B, Franke-Fayard B, Heussler V, van Dooren MW, van Schaijk B, van Gemert GJ, Sauerwein RW, Mota MM, Waters AP, Janse CJ. van Dijk MR, et al. Among authors: heussler v. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12194-9. doi: 10.1073/pnas.0500925102. Epub 2005 Aug 15. Proc Natl Acad Sci U S A. 2005. PMID: 16103357 Free PMC article.
Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes.
Sicard A, Semblat JP, Doerig C, Hamelin R, Moniatte M, Dorin-Semblat D, Spicer JA, Srivastava A, Retzlaff S, Heussler V, Waters AP, Doerig C. Sicard A, et al. Among authors: heussler v. Cell Microbiol. 2011 Jun;13(6):836-45. doi: 10.1111/j.1462-5822.2011.01582.x. Epub 2011 Mar 4. Cell Microbiol. 2011. PMID: 21371233 Free PMC article.
A key role for lipoic acid synthesis during Plasmodium liver stage development.
Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. Falkard B, et al. Among authors: heussler v. Cell Microbiol. 2013 Sep;15(9):1585-604. doi: 10.1111/cmi.12137. Epub 2013 Apr 5. Cell Microbiol. 2013. PMID: 23490300 Free PMC article.
124 results