Issaeva N - Search Results

1

Tumor-specific induction of apoptosis by a p53-reactivating compound.

Hedström E, Issaeva N, Enge M, Selivanova G. Hedström E, et al. Among authors: issaeva n. Exp Cell Res. 2009 Feb 1;315(3):451-61. doi: 10.1016/j.yexcr.2008.11.009. Epub 2008 Dec 3. Exp Cell Res. 2009. PMID: 19071110

2

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedström E, Issaeva N, Kel A, Arnér ES, Selivanova G. Shi Y, et al. Among authors: issaeva n. Cell Death Differ. 2014 Apr;21(4):612-23. doi: 10.1038/cdd.2013.186. Epub 2014 Jan 10. Cell Death Differ. 2014. PMID: 24413150 Free PMC article.

3

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P, Bergman J, Wiman KG, Selivanova G. Bykov VJ, et al. Among authors: issaeva n. Nat Med. 2002 Mar;8(3):282-8. doi: 10.1038/nm0302-282. Nat Med. 2002. PMID: 11875500

4

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.

Issaeva N, Friedler A, Bozko P, Wiman KG, Fersht AR, Selivanova G. Issaeva N, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13303-7. doi: 10.1073/pnas.1835733100. Epub 2003 Oct 31. Proc Natl Acad Sci U S A. 2003. PMID: 14595027 Free PMC article.

5

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G. Issaeva N, et al. Nat Med. 2004 Dec;10(12):1321-8. doi: 10.1038/nm1146. Epub 2004 Nov 21. Nat Med. 2004. PMID: 15558054

6

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

Bykov VJ, Issaeva N, Zache N, Shilov A, Hultcrantz M, Bergman J, Selivanova G, Wiman KG. Bykov VJ, et al. Among authors: issaeva n. J Biol Chem. 2005 Aug 26;280(34):30384-91. doi: 10.1074/jbc.M501664200. Epub 2005 Jul 1. J Biol Chem. 2005. PMID: 15998635 Free article.

7

PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo.

Bao W, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, Issaeva N, Selivanova G, Strömblad S. Bao W, et al. Among authors: issaeva n. Cell Cycle. 2011 Jan 15;10(2):301-7. doi: 10.4161/cc.10.2.14538. Epub 2011 Jan 15. Cell Cycle. 2011. PMID: 21239882

8

Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis.

Heessen S, Leonchiks A, Issaeva N, Sharipo A, Selivanova G, Masucci MG, Dantuma NP. Heessen S, et al. Among authors: issaeva n. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1532-7. doi: 10.1073/pnas.022306499. Epub 2002 Jan 22. Proc Natl Acad Sci U S A. 2002. PMID: 11805282 Free PMC article.

9

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

Bykov VJ, Issaeva N, Selivanova G, Wiman KG. Bykov VJ, et al. Among authors: issaeva n. Carcinogenesis. 2002 Dec;23(12):2011-8. doi: 10.1093/carcin/23.12.2011. Carcinogenesis. 2002. PMID: 12507923

10

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.

Grinkevich VV, Vema A, Fawkner K, Issaeva N, Andreotti V, Dickinson ER, Hedström E, Spinnler C, Inga A, Larsson LG, Karlén A, Wilhelm M, Barran PE, Okorokov AL, Selivanova G, Zawacka-Pankau JE. Grinkevich VV, et al. Among authors: issaeva n. Front Mol Biosci. 2022 Jun 1;9:823195. doi: 10.3389/fmolb.2022.823195. eCollection 2022. Front Mol Biosci. 2022. PMID: 35720128 Free PMC article.

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