Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.
Selivanova G, Ryabchenko L, Jansson E, Iotsova V, Wiman KG.
Selivanova G, et al.
Mol Cell Biol. 1999 May;19(5):3395-402. doi: 10.1128/MCB.19.5.3395.
Mol Cell Biol. 1999.
PMID: 10207063
Free PMC article.
A synthetic 22-mer peptide (peptide 46) derived from the p53 C-terminal domain can restore the growth suppressor function of mutant p53 proteins in human tumor cells (G. Selivanova et al., Nat. Med. 3:632-638, 1997). Here we demonstrate that peptide 46 binds mutant …
A synthetic 22-mer peptide (peptide 46) derived from the p53 C-terminal domain can restore the growth suppressor function of mutant p53 prot …