Brown AK - Search Results

1

The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.

Veyron-Churlet R, Molle V, Taylor RC, Brown AK, Besra GS, Zanella-Cléon I, Fütterer K, Kremer L. Veyron-Churlet R, et al. Among authors: brown ak. J Biol Chem. 2009 Mar 6;284(10):6414-24. doi: 10.1074/jbc.M806537200. Epub 2008 Dec 11. J Biol Chem. 2009. PMID: 19074144 Free PMC article.

2

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS. Kremer L, et al. Among authors: brown ak. Biochem J. 2002 Jun 1;364(Pt 2):423-30. doi: 10.1042/BJ20011628. Biochem J. 2002. PMID: 12023885 Free PMC article.

3

Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

Gande R, Gibson KJ, Brown AK, Krumbach K, Dover LG, Sahm H, Shioyama S, Oikawa T, Besra GS, Eggeling L. Gande R, et al. Among authors: brown ak. J Biol Chem. 2004 Oct 22;279(43):44847-57. doi: 10.1074/jbc.M408648200. Epub 2004 Aug 11. J Biol Chem. 2004. PMID: 15308633 Free article.

4

Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum.

Radmacher E, Alderwick LJ, Besra GS, Brown AK, Gibson KJC, Sahm H, Eggeling L. Radmacher E, et al. Among authors: brown ak. Microbiology (Reading). 2005 Jul;151(Pt 7):2421-2427. doi: 10.1099/mic.0.28012-0. Microbiology (Reading). 2005. PMID: 16000732 Free article.

5

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS. Brown AK, et al. J Biol Chem. 2005 Sep 16;280(37):32539-47. doi: 10.1074/jbc.M413216200. Epub 2005 Jul 22. J Biol Chem. 2005. PMID: 16040614 Free article.

6

The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.

Molle V, Brown AK, Besra GS, Cozzone AJ, Kremer L. Molle V, et al. Among authors: brown ak. J Biol Chem. 2006 Oct 6;281(40):30094-103. doi: 10.1074/jbc.M601691200. Epub 2006 Jul 27. J Biol Chem. 2006. PMID: 16873379 Free article.

7

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.

Bhowruth V, Brown AK, Reynolds RC, Coxon GD, Mackay SP, Minnikin DE, Besra GS. Bhowruth V, et al. Among authors: brown ak. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4743-7. doi: 10.1016/j.bmcl.2006.06.095. Epub 2006 Jul 27. Bioorg Med Chem Lett. 2006. PMID: 16875817

8

X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

Sridharan S, Wang L, Brown AK, Dover LG, Kremer L, Besra GS, Sacchettini JC. Sridharan S, et al. Among authors: brown ak. J Mol Biol. 2007 Feb 16;366(2):469-80. doi: 10.1016/j.jmb.2006.11.006. Epub 2006 Nov 7. J Mol Biol. 2007. PMID: 17174327 Free PMC article.

9

Regulation of cell wall synthesis and growth.

Dover LG, Alderwick LJ, Brown AK, Futterer K, Besra GS. Dover LG, et al. Among authors: brown ak. Curr Mol Med. 2007 May;7(3):247-76. doi: 10.2174/156652407780598601. Curr Mol Med. 2007. PMID: 17504111 Review.

10

Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+.

Brown AK, Meng G, Ghadbane H, Scott DJ, Dover LG, Nigou J, Besra GS, Fütterer K. Brown AK, et al. BMC Struct Biol. 2007 Aug 28;7:55. doi: 10.1186/1472-6807-7-55. BMC Struct Biol. 2007. PMID: 17725819 Free PMC article.

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