Rodríguez-González A - Search Results

1

Choline kinase alpha depletion selectively kills tumoral cells.

Bañez-Coronel M, Ramírez de Molina A, Rodríguez-González A, Sarmentero J, Ramos MA, García-Cabezas MA, García-Oroz L, Lacal JC. Bañez-Coronel M, et al. Curr Cancer Drug Targets. 2008 Dec;8(8):709-19. doi: 10.2174/156800908786733432. Curr Cancer Drug Targets. 2008. PMID: 19075594

2

Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets.

Rodríguez-González A, Ramírez de Molina A, Benítez-Rajal J, Lacal JC. Rodríguez-González A, et al. Prog Cell Cycle Res. 2003;5:191-201. Prog Cell Cycle Res. 2003. PMID: 14593713 Review.

3

From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design.

Ramírez de Molina A, Rodríguez-González A, Lacal JC. Ramírez de Molina A, et al. Cancer Lett. 2004 Apr 8;206(2):137-48. doi: 10.1016/j.canlet.2003.08.031. Cancer Lett. 2004. PMID: 15013519 Review.

4

Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression.

Ramírez de Molina A, Báñez-Coronel M, Gutiérrez R, Rodríguez-González A, Olmeda D, Megías D, Lacal JC. Ramírez de Molina A, et al. Cancer Res. 2004 Sep 15;64(18):6732-9. doi: 10.1158/0008-5472.CAN-04-0489. Cancer Res. 2004. PMID: 15374991

5

Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.

Rodríguez-González A, Ramirez de Molina A, Fernández F, Lacal JC. Rodríguez-González A, et al. Oncogene. 2004 Oct 28;23(50):8247-59. doi: 10.1038/sj.onc.1208045. Oncogene. 2004. PMID: 15378008

6

Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism.

Rodríguez-González A, Ramírez de Molina A, Bañez-Coronel M, Megias D, Lacal JC. Rodríguez-González A, et al. Int J Oncol. 2005 Apr;26(4):999-1008. Int J Oncol. 2005. PMID: 15753995

7

Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.

Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, Martínez-Piñeiro L, Sánchez J, Bonilla F, Rosell R, Lacal J. Ramírez de Molina A, et al. Biochem Biophys Res Commun. 2002 Aug 23;296(3):580-3. doi: 10.1016/s0006-291x(02)00920-8. Biochem Biophys Res Commun. 2002. PMID: 12176020

8

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.

Rodríguez-González A, Ramírez de Molina A, Fernández F, Ramos MA, del Carmen Núñez M, Campos J, Lacal JC. Rodríguez-González A, et al. Oncogene. 2003 Dec 4;22(55):8803-12. doi: 10.1038/sj.onc.1207062. Oncogene. 2003. PMID: 14654777

9

A novel 4,4'-bispyridyl-5,5'-perfluoroalkyl-2,2'-bisoxazol with antitumoral activity via cell cycle arrest and induction of apoptosis.

Báñez-Coronel M, Rodríguez-González A, Martín-Cantalejo Y, Sáez B, Soto J, Villa MJ, Braña MF, Lacal JC. Báñez-Coronel M, et al. Int J Oncol. 2004 Oct;25(4):1097-103. Int J Oncol. 2004. PMID: 15375561

10

Influence of the linker in bispyridium compounds on the inhibition of human choline kinase.

Conejo-García A, Báñez-Coronel M, Sánchez-Martín RM, Rodríguez-González A, Ramos A, Ramírez de Molina A, Espinosa A, Gallo MA, Campos JM, Lacal JC. Conejo-García A, et al. J Med Chem. 2004 Oct 21;47(22):5433-40. doi: 10.1021/jm0496537. J Med Chem. 2004. PMID: 15481981

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