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Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.
Evindar G, Bernier SG, Kavarana MJ, Doyle E, Lorusso J, Kelley MS, Halley K, Hutchings A, Wright AD, Saha AK, Hannig G, Morgan BA, Westlin WF. Evindar G, et al. Among authors: saha ak. Bioorg Med Chem Lett. 2009 Jan 15;19(2):369-72. doi: 10.1016/j.bmcl.2008.11.072. Epub 2008 Nov 24. Bioorg Med Chem Lett. 2009. PMID: 19081720
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.
Evindar G, Satz AL, Bernier SG, Kavarana MJ, Doyle E, Lorusso J, Taghizadeh N, Halley K, Hutchings A, Kelley MS, Wright AD, Saha AK, Hannig G, Morgan BA, Westlin WF. Evindar G, et al. Among authors: saha ak. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2315-9. doi: 10.1016/j.bmcl.2009.02.073. Epub 2009 Feb 23. Bioorg Med Chem Lett. 2009. PMID: 19282175
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS.
Saha AK, Yu X, Lin J, Lobera M, Sharadendu A, Chereku S, Schutz N, Segal D, Marantz Y, McCauley D, Middleton S, Siu J, Bürli RW, Buys J, Horner M, Salyers K, Schrag M, Vargas HM, Xu Y, McElvain M, Xu H. Saha AK, et al. ACS Med Chem Lett. 2010 Nov 9;2(2):97-101. doi: 10.1021/ml100227q. eCollection 2011 Feb 10. ACS Med Chem Lett. 2010. PMID: 24900286 Free PMC article.
4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
Angibaud P, Saha AK, Bourdrez X, End DW, Freyne E, Lezouret P, Mannens G, Mevellec L, Meyer C, Pilatte I, Poncelet V, Roux B, Smets G, Van Dun J, Venet M, Wouters W. Angibaud P, et al. Among authors: saha ak. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4361-4. doi: 10.1016/j.bmcl.2003.09.043. Bioorg Med Chem Lett. 2003. PMID: 14643326
Novel triazole based inhibitors of Ras farnesyl transferase.
Saha AK, Liu L, Simoneaux R, DeCorte B, Meyer C, Skrzat S, Breslin HJ, Kukla MJ, End DW. Saha AK, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5407-11. doi: 10.1016/j.bmcl.2005.09.007. Epub 2005 Oct 10. Bioorg Med Chem Lett. 2005. PMID: 16216509
422 results