Shakya R - Search Results

1

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T. Reid LJ, et al. Among authors: shakya r. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20876-81. doi: 10.1073/pnas.0811203106. Epub 2008 Dec 16. Proc Natl Acad Sci U S A. 2008. PMID: 19088202 Free PMC article.

2

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.

Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T. Shakya R, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. doi: 10.1073/pnas.0711032105. Epub 2008 Apr 28. Proc Natl Acad Sci U S A. 2008. PMID: 18443292 Free PMC article.

3

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity.

Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T. Shakya R, et al. Science. 2011 Oct 28;334(6055):525-8. doi: 10.1126/science.1209909. Science. 2011. PMID: 22034435 Free PMC article.

4

The DNA resection protein CtIP promotes mammary tumorigenesis.

Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R. Reczek CR, et al. Among authors: shakya r. Oncotarget. 2016 May 31;7(22):32172-83. doi: 10.18632/oncotarget.8605. Oncotarget. 2016. PMID: 27058754 Free PMC article.

5

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

Park D, Shakya R, Koivisto C, Pitarresi JR, Szabolcs M, Kladney R, Hadjis A, Mace TA, Ludwig T. Park D, et al. Among authors: shakya r. PLoS One. 2019 Dec 26;14(12):e0226714. doi: 10.1371/journal.pone.0226714. eCollection 2019. PLoS One. 2019. PMID: 31877165 Free PMC article.

6

Ablation of the Brca1-Palb2 Interaction Phenocopies Fanconi Anemia in Mice.

Park D, Bergin SM, Jones D, Ru P, Koivisto CS, Jeon YJ, Sizemore GM, Kladney RD, Hadjis A, Shakya R, Ludwig T. Park D, et al. Among authors: shakya r. Cancer Res. 2020 Oct 1;80(19):4172-4184. doi: 10.1158/0008-5472.CAN-20-0486. Epub 2020 Jul 30. Cancer Res. 2020. PMID: 32732220

7

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

Shakya R, Gonda T, Quante M, Salas M, Kim S, Brooks J, Hirsch S, Davies J, Cullo A, Olive K, Wang TC, Szabolcs M, Tycko B, Ludwig T. Shakya R, et al. Cancer Res. 2013 Jan 15;73(2):885-96. doi: 10.1158/0008-5472.CAN-12-1880. Epub 2012 Nov 29. Cancer Res. 2013. PMID: 23204224 Free PMC article.

8

The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression.

Sonabend AM, Bansal M, Guarnieri P, Lei L, Amendolara B, Soderquist C, Leung R, Yun J, Kennedy B, Sisti J, Bruce S, Bruce R, Shakya R, Ludwig T, Rosenfeld S, Sims PA, Bruce JN, Califano A, Canoll P. Sonabend AM, et al. Among authors: shakya r. Cancer Res. 2014 Mar 1;74(5):1440-1451. doi: 10.1158/0008-5472.CAN-13-2150. Epub 2014 Jan 3. Cancer Res. 2014. PMID: 24390738 Free PMC article.

9

High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions.

Lucas AL, Shakya R, Lipsyc MD, Mitchel EB, Kumar S, Hwang C, Deng L, Devoe C, Chabot JA, Szabolcs M, Ludwig T, Chung WK, Frucht H. Lucas AL, et al. Among authors: shakya r. Clin Cancer Res. 2013 Jul 1;19(13):3396-403. doi: 10.1158/1078-0432.CCR-12-3020. Epub 2013 May 8. Clin Cancer Res. 2013. PMID: 23658460 Free PMC article.

10

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB. Mace TA, et al. Among authors: shakya r. Gut. 2018 Feb;67(2):320-332. doi: 10.1136/gutjnl-2016-311585. Epub 2016 Oct 21. Gut. 2018. PMID: 27797936 Free PMC article.

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