Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions.
Hober S, Lundström Ljung J, Uhlén M, Nilsson B.
Hober S, et al.
FEBS Lett. 1999 Jan 29;443(3):271-6. doi: 10.1016/s0014-5793(98)01737-2.
FEBS Lett. 1999.
PMID: 10025946
Free article.
Insulin-like growth factor (IGF) I does not quantitatively form its three native disulfide bonds in the presence of 10 mM reduced and 1 mM oxidized glutathione in vitro [Hober, S. et al. (1992) Biochemistry 31, 1749-1756]. In this paper, we show (i) that both IGF-I …
Insulin-like growth factor (IGF) I does not quantitatively form its three native disulfide bonds in the presence of 10 mM reduced and 1 mM o …