Sacchettini JC - Search Results

1

Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.

Freundlich JS, Wang F, Vilchèze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC. Freundlich JS, et al. Among authors: sacchettini jc. ChemMedChem. 2009 Feb;4(2):241-8. doi: 10.1002/cmdc.200800261. ChemMedChem. 2009. PMID: 19130456 Free PMC article.

2

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

Quémard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS. Quémard A, et al. Among authors: sacchettini jc. Biochemistry. 1995 Jul 4;34(26):8235-41. doi: 10.1021/bi00026a004. Biochemistry. 1995. PMID: 7599116

3

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.

Dessen A, Quémard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC. Dessen A, et al. Among authors: sacchettini jc. Science. 1995 Mar 17;267(5204):1638-41. doi: 10.1126/science.7886450. Science. 1995. PMID: 7886450

4

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC. Rozwarski DA, et al. Among authors: sacchettini jc. Science. 1998 Jan 2;279(5347):98-102. doi: 10.1126/science.279.5347.98. Science. 1998. PMID: 9417034

5

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.

Klabunde T, Sharma S, Telenti A, Jacobs WR Jr, Sacchettini JC. Klabunde T, et al. Among authors: sacchettini jc. Nat Struct Biol. 1998 Jan;5(1):31-6. doi: 10.1038/nsb0198-31. Nat Struct Biol. 1998. PMID: 9437427

6

The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR. Banerjee A, et al. Among authors: sacchettini jc. Microbiology (Reading). 1998 Oct;144 ( Pt 10):2697-2704. doi: 10.1099/00221287-144-10-2697. Microbiology (Reading). 1998. PMID: 9802011 Free article.

7

Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

Sharma V, Grubmeyer C, Sacchettini JC. Sharma V, et al. Among authors: sacchettini jc. Structure. 1998 Dec 15;6(12):1587-99. doi: 10.1016/s0969-2126(98)00156-7. Structure. 1998. PMID: 9862811 Free article.

8

Mechanisms for isoniazid action and resistance.

Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR Jr. Miesel L, et al. Among authors: sacchettini jc. Novartis Found Symp. 1998;217:209-20; discussion 220-1. doi: 10.1002/0470846526.ch15. Novartis Found Symp. 1998. PMID: 9949810 Review.

9

Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.

Rozwarski DA, Vilchèze C, Sugantino M, Bittman R, Sacchettini JC. Rozwarski DA, et al. Among authors: sacchettini jc. J Biol Chem. 1999 May 28;274(22):15582-9. doi: 10.1074/jbc.274.22.15582. J Biol Chem. 1999. PMID: 10336454 Free article.

10

Rational design of potent human transthyretin amyloid disease inhibitors.

Klabunde T, Petrassi HM, Oza VB, Raman P, Kelly JW, Sacchettini JC. Klabunde T, et al. Among authors: sacchettini jc. Nat Struct Biol. 2000 Apr;7(4):312-21. doi: 10.1038/74082. Nat Struct Biol. 2000. PMID: 10742177

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