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Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.
Dazert E, Neumann-Haefelin C, Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen HR, Shaw J, Bowness P, Blum HE, Klenerman P, Bartenschlager R, Thimme R. Dazert E, et al. Among authors: kelleher d. J Clin Invest. 2009 Feb;119(2):376-86. doi: 10.1172/JCI36587. Epub 2009 Jan 12. J Clin Invest. 2009. PMID: 19139562 Free PMC article.
Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope.
Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Neumann-Haefelin C, et al. Among authors: kelleher d. Hepatology. 2010 Jan;51(1):54-62. doi: 10.1002/hep.23275. Hepatology. 2010. PMID: 20034048 Free PMC article.
Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.
Lucas M, Deshpande P, James I, Rauch A, Pfafferott K, Gaylard E, Merani S, Plauzolles A, Lucas A, McDonnell W, Kalams S, Pilkinton M, Chastain C, Barnett L, Prosser A, Mallal S, Fitzmaurice K, Drummer H, Ansari MA, Pedergnana V, Barnes E, John M, Kelleher D, Klenerman P, Gaudieri S. Lucas M, et al. Among authors: kelleher d. Sci Rep. 2018 May 8;8(1):7224. doi: 10.1038/s41598-018-25559-6. Sci Rep. 2018. PMID: 29740042 Free PMC article.
Immunogenetics of hepatitis C virus.
McKiernan S, Kelleher D. McKiernan S, et al. Among authors: kelleher d. J Viral Hepat. 2000 May;7 Suppl 1:13-4. doi: 10.1046/j.1365-2893.2000.00022.x. J Viral Hepat. 2000. PMID: 10866840 Review.
552 results