Xu Y - Search Results

1

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.

Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VM. Igaz LM, et al. Among authors: xu y. J Biol Chem. 2009 Mar 27;284(13):8516-24. doi: 10.1074/jbc.M809462200. Epub 2009 Jan 21. J Biol Chem. 2009. PMID: 19164285 Free PMC article.

2

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.

Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL 3rd, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, Mackenzie IR. Cairns NJ, et al. Among authors: xu y. Am J Pathol. 2007 Jul;171(1):227-40. doi: 10.2353/ajpath.2007.070182. Am J Pathol. 2007. PMID: 17591968 Free PMC article.

3

Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.

Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Geser F, et al. Among authors: xu y. Acta Neuropathol. 2008 Jan;115(1):133-45. doi: 10.1007/s00401-007-0257-y. Epub 2007 Aug 23. Acta Neuropathol. 2008. PMID: 17713769

4

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Igaz LM, Kwong LK, Xu Y, Truax AC, Uryu K, Neumann M, Clark CM, Elman LB, Miller BL, Grossman M, McCluskey LF, Trojanowski JQ, Lee VM. Igaz LM, et al. Among authors: xu y. Am J Pathol. 2008 Jul;173(1):182-94. doi: 10.2353/ajpath.2008.080003. Epub 2008 Jun 5. Am J Pathol. 2008. PMID: 18535185 Free PMC article.

5

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.

Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Neumann M, et al. Among authors: xu y. Acta Neuropathol. 2009 Feb;117(2):137-49. doi: 10.1007/s00401-008-0477-9. Epub 2009 Jan 6. Acta Neuropathol. 2009. PMID: 19125255 Free PMC article.

6

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Igaz LM, et al. Among authors: xu y. J Clin Invest. 2011 Feb;121(2):726-38. doi: 10.1172/JCI44867. Epub 2011 Jan 4. J Clin Invest. 2011. PMID: 21206091 Free PMC article.

7

Distinct α-synuclein strains differentially promote tau inclusions in neurons.

Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM. Guo JL, et al. Among authors: xu y. Cell. 2013 Jul 3;154(1):103-17. doi: 10.1016/j.cell.2013.05.057. Cell. 2013. PMID: 23827677 Free PMC article.

8

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins.

Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM. Kwong LK, et al. Among authors: xu y. Acta Neuropathol Commun. 2014 Mar 31;2:33. doi: 10.1186/2051-5960-2-33. Acta Neuropathol Commun. 2014. PMID: 24690345 Free PMC article.

9

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.

Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM. Walker AK, et al. Among authors: xu y. Acta Neuropathol. 2015 Nov;130(5):643-60. doi: 10.1007/s00401-015-1460-x. Epub 2015 Jul 22. Acta Neuropathol. 2015. PMID: 26197969 Free PMC article.

10

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice.

Walker AK, Tripathy K, Restrepo CR, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM. Walker AK, et al. Among authors: xu y. Hum Mol Genet. 2015 Dec 20;24(25):7241-54. doi: 10.1093/hmg/ddv424. Epub 2015 Oct 16. Hum Mol Genet. 2015. PMID: 26476406 Free PMC article.

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