Frederick CB - Search Results

1

Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.

Powley MW, Frederick CB, Sistare FD, DeGeorge JJ. Powley MW, et al. Among authors: frederick cb. Chem Res Toxicol. 2009 Feb;22(2):257-62. doi: 10.1021/tx8004373. Chem Res Toxicol. 2009. PMID: 19170595

2

Metabolites in safety testing: "MIST" for the clinical pharmacologist.

Frederick CB, Obach RS. Frederick CB, et al. Clin Pharmacol Ther. 2010 Mar;87(3):345-50. doi: 10.1038/clpt.2009.283. Epub 2010 Jan 27. Clin Pharmacol Ther. 2010. PMID: 20107437 Review. No abstract available.

3

Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats.

Schaefer WH, Lawrence JW, Loughlin AF, Stoffregen DA, Mixson LA, Dean DC, Raab CE, Yu NX, Lankas GR, Frederick CB. Schaefer WH, et al. Among authors: frederick cb. Toxicol Appl Pharmacol. 2004 Jan 1;194(1):10-23. doi: 10.1016/j.taap.2003.08.013. Toxicol Appl Pharmacol. 2004. PMID: 14728975

4

CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist.

Tang C, Carr BA, Poignant F, Ma B, Polsky-Fisher SL, Kuo Y, Strong-Basalyga K, Norcross A, Richards K, Eisenhandler R, Carlini EJ, Di Marco CN, Kuduk SD, Yu NX, Raab CE, Rushmore T, Frederick CB, Bock MG, Prueksaritanont T. Tang C, et al. Among authors: frederick cb. J Pharmacol Exp Ther. 2008 Jun;325(3):935-46. doi: 10.1124/jpet.107.136044. Epub 2008 Feb 29. J Pharmacol Exp Ther. 2008. PMID: 18310472

5

Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors.

Frederick CB, Lomax LG, Black KA, Finch L, Scribner HE, Kimbell JS, Morgan KT, Subramaniam RP, Morris JB. Frederick CB, et al. Toxicol Appl Pharmacol. 2002 Aug 15;183(1):23-40. doi: 10.1006/taap.2002.9451. Toxicol Appl Pharmacol. 2002. PMID: 12217639

6

A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment.

Frederick CB, Potter DW, Chang-Mateu MI, Andersen ME. Frederick CB, et al. Toxicol Appl Pharmacol. 1992 Jun;114(2):246-60. doi: 10.1016/0041-008x(92)90075-4. Toxicol Appl Pharmacol. 1992. PMID: 1609417

7

Summary of panel discussion on the 'advantages/limitations/uncertainties in the use of physiologically based pharmacokinetic and pharmacodynamic models in hazard identification and risk assessment of toxic substances'.

Frederick CB. Frederick CB. Toxicol Lett. 1995 Sep;79(1-3):201-6. doi: 10.1016/0378-4274(95)03371-q. Toxicol Lett. 1995. PMID: 7570657 Review.

8

Native Oxyntomodulin Has Significant Glucoregulatory Effects Independent of Weight Loss in Obese Humans With and Without Type 2 Diabetes.

Shankar SS, Shankar RR, Mixson LA, Miller DL, Pramanik B, O'Dowd AK, Williams DM, Frederick CB, Beals CR, Stoch SA, Steinberg HO, Kelley DE. Shankar SS, et al. Among authors: frederick cb. Diabetes. 2018 Jun;67(6):1105-1112. doi: 10.2337/db17-1331. Epub 2018 Mar 15. Diabetes. 2018. PMID: 29545266 Clinical Trial.

9

Rate and route of oxidation of acrylic acid to carbon dioxide in rat liver.

Finch L, Frederick CB. Finch L, et al. Among authors: frederick cb. Fundam Appl Toxicol. 1992 Nov;19(4):498-504. doi: 10.1016/0272-0590(92)90087-x. Fundam Appl Toxicol. 1992. PMID: 1426707

10

The regional hydrolysis of ethyl acrylate to acrylic acid in the rat nasal cavity.

Frederick CB, Udinsky JR, Finch L. Frederick CB, et al. Toxicol Lett. 1994 Jan;70(1):49-56. doi: 10.1016/0378-4274(94)90143-0. Toxicol Lett. 1994. PMID: 8310456

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