Sabatini DM - Search Results

1

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Cancer Cell. 2009 Feb 3;15(2):148-59. doi: 10.1016/j.ccr.2008.12.017. Cancer Cell. 2009. PMID: 19185849 Free PMC article.

2

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation.

Peng T, Golub TR, Sabatini DM. Peng T, et al. Among authors: sabatini dm. Mol Cell Biol. 2002 Aug;22(15):5575-84. doi: 10.1128/MCB.22.15.5575-5584.2002. Mol Cell Biol. 2002. PMID: 12101249 Free PMC article.

3

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Cell. 2002 Jul 26;110(2):163-75. doi: 10.1016/s0092-8674(02)00808-5. Cell. 2002. PMID: 12150925 Free article.

4

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Mol Cell. 2003 Apr;11(4):895-904. doi: 10.1016/s1097-2765(03)00114-x. Mol Cell. 2003. PMID: 12718876 Free article.

5

Raptor and mTOR: subunits of a nutrient-sensitive complex.

Kim DH, Sabatini DM. Kim DH, et al. Among authors: sabatini dm. Curr Top Microbiol Immunol. 2004;279:259-70. doi: 10.1007/978-3-642-18930-2_15. Curr Top Microbiol Immunol. 2004. PMID: 14560962 Review.

6

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Curr Biol. 2004 Jul 27;14(14):1296-302. doi: 10.1016/j.cub.2004.06.054. Curr Biol. 2004. PMID: 15268862 Free article.

7

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Sarbassov DD, et al. Among authors: sabatini dm. Science. 2005 Feb 18;307(5712):1098-101. doi: 10.1126/science.1106148. Science. 2005. PMID: 15718470

8

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells.

Wheeler DB, Bailey SN, Guertin DA, Carpenter AE, Higgins CO, Sabatini DM. Wheeler DB, et al. Among authors: sabatini dm. Nat Methods. 2004 Nov;1(2):127-32. doi: 10.1038/nmeth711. Epub 2004 Oct 21. Nat Methods. 2004. PMID: 15782175

9

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

Ali SM, Sabatini DM. Ali SM, et al. Among authors: sabatini dm. J Biol Chem. 2005 May 20;280(20):19445-8. doi: 10.1074/jbc.C500125200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15809305 Free article.

10

An expanding role for mTOR in cancer.

Guertin DA, Sabatini DM. Guertin DA, et al. Among authors: sabatini dm. Trends Mol Med. 2005 Aug;11(8):353-61. doi: 10.1016/j.molmed.2005.06.007. Trends Mol Med. 2005. PMID: 16002336 Review.

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