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The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.
Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF. Billon-Galés A, et al. Among authors: flouriot g. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2053-8. doi: 10.1073/pnas.0808742106. Epub 2009 Feb 2. Proc Natl Acad Sci U S A. 2009. PMID: 19188600 Free PMC article.
Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.
Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF. Billon-Galés A, et al. Among authors: flouriot g. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6. doi: 10.1073/pnas.1105632108. Epub 2011 Jul 25. Proc Natl Acad Sci U S A. 2011. PMID: 21788522 Free PMC article.
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.
Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF. Abot A, et al. Among authors: flouriot g. EMBO Mol Med. 2014 Oct;6(10):1328-46. doi: 10.15252/emmm.201404112. EMBO Mol Med. 2014. PMID: 25214462 Free PMC article.
82 results