Cusack K - Search Results

1

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production.

Cusack K, Allen H, Bischoff A, Clabbers A, Dixon R, Fix-Stenzel S, Friedman M, Gaumont Y, George D, Gordon T, Grongsaard P, Janssen B, Jia Y, Moskey M, Quinn C, Salmeron A, Thomas C, Wallace G, Wishart N, Yu Z. Cusack K, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1722-5. doi: 10.1016/j.bmcl.2009.01.088. Epub 2009 Jan 30. Bioorg Med Chem Lett. 2009. PMID: 19217782

2

A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules.

Cusack KP, Arnold LD, Barberis CE, Chen H, Ericsson AM, Gaza-Bulseco GS, Gordon TD, Grinnell CM, Harsch A, Pellegrini M, Tarcsa E. Cusack KP, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5503-7. doi: 10.1016/j.bmcl.2004.09.007. Bioorg Med Chem Lett. 2004. PMID: 15482913

3

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors.

George D, Friedman M, Allen H, Argiriadi M, Barberis C, Bischoff A, Clabbers A, Cusack K, Dixon R, Fix-Stenzel S, Gordon T, Janssen B, Jia Y, Moskey M, Quinn C, Salmeron JA, Wishart N, Woller K, Yu Z. George D, et al. Among authors: cusack k. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4952-5. doi: 10.1016/j.bmcl.2008.08.037. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18755587

4

Scalable synthesis and isolation of the four stereoisomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate, useful intermediates for the synthesis of S1P1 receptor agonists.

Wallace GA, Gordon TD, Hayes ME, Konopacki DB, Fix-Stenzel SR, Zhang X, Grongsaard P, Cusack KP, Schaffter LM, Henry RF, Stoffel RH. Wallace GA, et al. J Org Chem. 2009 Jul 3;74(13):4886-9. doi: 10.1021/jo900376b. J Org Chem. 2009. PMID: 19489574

5

Identification of potent and selective inhibitors of PKR via virtual screening and traditional design.

Cusack KP, Argiriadi MA, Gordon TD, Harris CM, Herold JM, Hoemann MZ, Yestrepsky BD. Cusack KP, et al. Bioorg Med Chem Lett. 2023 Jan 1;79:129047. doi: 10.1016/j.bmcl.2022.129047. Epub 2022 Nov 15. Bioorg Med Chem Lett. 2023. PMID: 36400288

6

Emerging technologies for metabolite generation and structural diversification.

Cusack KP, Koolman HF, Lange UE, Peltier HM, Piel I, Vasudevan A. Cusack KP, et al. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5471-83. doi: 10.1016/j.bmcl.2013.08.003. Epub 2013 Aug 11. Bioorg Med Chem Lett. 2013. PMID: 23992859 Free article.

7

Design strategies to address kinetics of drug binding and residence time.

Cusack KP, Wang Y, Hoemann MZ, Marjanovic J, Heym RG, Vasudevan A. Cusack KP, et al. Bioorg Med Chem Lett. 2015;25(10):2019-27. doi: 10.1016/j.bmcl.2015.02.027. Epub 2015 Mar 5. Bioorg Med Chem Lett. 2015. PMID: 25782745 Review.

8

Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors.

George DM, Huntley RJ, Cusack K, Duignan DB, Hoemann M, Loud J, Mario R, Melim T, Mullen K, Somal G, Wang L, Edmunds JJ. George DM, et al. Among authors: cusack k. PLoS One. 2018 Sep 7;13(9):e0203567. doi: 10.1371/journal.pone.0203567. eCollection 2018. PLoS One. 2018. PMID: 30192846 Free PMC article.

9

Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists.

Amaudrut J, Argiriadi MA, Barth M, Breinlinger EC, Bressac D, Broqua P, Calderwood DJ, Chatar M, Cusack KP, Gauld SB, Jacquet S, Kamath RV, Kort ME, Lepais V, Luccarini JM, Masson P, Montalbetti C, Mounier L, Potin D, Poupardin O, Rouaud S, Spitzer L, Wallace CD. Amaudrut J, et al. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1799-1806. doi: 10.1016/j.bmcl.2019.05.015. Epub 2019 May 9. Bioorg Med Chem Lett. 2019. PMID: 31101472

10

32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis.

Frye LL, Cusack KP, Leonard DA. Frye LL, et al. Among authors: cusack kp. J Med Chem. 1993 Feb 5;36(3):410-6. doi: 10.1021/jm00055a012. J Med Chem. 1993. PMID: 8426367

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