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Synthesis and bioevaluation of omega-N-amino analogs of B13.
Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: bielawska a. Bioorg Med Chem. 2009 Mar 1;17(5):1840-8. doi: 10.1016/j.bmc.2009.01.057. Epub 2009 Jan 31. Bioorg Med Chem. 2009. PMID: 19217788 Free PMC article.
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential anticancer agents deprived of unwanted lysosomal destabilization and ACDase proteolytic degradation properties of LCL204 [Szulc, Z. M.; Mayro …
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential a …
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: bielawska a. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22. Bioorg Med Chem. 2014. PMID: 25456083 Free PMC article.
289 results