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Synthesis and bioevaluation of omega-N-amino analogs of B13.
Bai A, Szulc ZM, Bielawski J, Mayroo N, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: liu x. Bioorg Med Chem. 2009 Mar 1;17(5):1840-8. doi: 10.1016/j.bmc.2009.01.057. Epub 2009 Jan 31. Bioorg Med Chem. 2009. PMID: 19217788 Free PMC article.
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential anticancer agents deprived of unwanted lysosomal destabilization and ACDase proteolytic degradation properties of LCL204 [Szulc, Z. M.; Mayro …
Novel omega-N-amino analogs of B13 (Class E) were designed, synthesized and tested as inhibitors of acid ceramidase (ACDase) and potential a …
New insights on the use of desipramine as an inhibitor for acid ceramidase.
Elojeimy S, Holman DH, Liu X, El-Zawahry A, Villani M, Cheng JC, Mahdy A, Zeidan Y, Bielwaska A, Hannun YA, Norris JS. Elojeimy S, et al. Among authors: liu x. FEBS Lett. 2006 Aug 21;580(19):4751-6. doi: 10.1016/j.febslet.2006.07.071. Epub 2006 Aug 4. FEBS Lett. 2006. PMID: 16901483 Free article.
Involvement of sphingolipids in apoptin-induced cell killing.
Liu X, Zeidan YH, Elojeimy S, Holman DH, El-Zawahry AM, Guo GW, Bielawska A, Bielawski J, Szulc Z, Rubinchik S, Dong JY, Keane TE, Tavassoli M, Hannun YA, Norris JS. Liu X, et al. Mol Ther. 2006 Nov;14(5):627-36. doi: 10.1016/j.ymthe.2006.07.001. Epub 2006 Aug 22. Mol Ther. 2006. PMID: 16926120 Free article.
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy.
Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, Meacham WD, Mahdy AE, Saad AF, Turner LS, Cheng J, A Day T, Dong JY, Bielawska A, Hannun YA, Norris JS. Elojeimy S, et al. Among authors: liu x. Mol Ther. 2007 Jul;15(7):1259-63. doi: 10.1038/sj.mt.6300167. Epub 2007 Apr 10. Mol Ther. 2007. PMID: 17426710 Free article.
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, Szulc ZM, Norris K, Zeidan YH, Hannun YA, Bielawska A, Norris JS. Holman DH, et al. Among authors: liu x. Cancer Chemother Pharmacol. 2008 Feb;61(2):231-42. doi: 10.1007/s00280-007-0465-0. Epub 2007 Apr 12. Cancer Chemother Pharmacol. 2008. PMID: 17429631
137,755 results
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