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Page 1
Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
Wagner R, Larson DP, Beno DW, Bosse TD, Darbyshire JF, Gao Y, Gates BD, He W, Henry RF, Hernandez LE, Hutchinson DK, Jiang WW, Kati WM, Klein LL, Koev G, Kohlbrenner W, Krueger AC, Liu J, Liu Y, Long MA, Maring CJ, Masse SV, Middleton T, Montgomery DA, Pratt JK, Stuart P, Molla A, Kempf DJ. Wagner R, et al. Among authors: klein ll. J Med Chem. 2009 Mar 26;52(6):1659-69. doi: 10.1021/jm8010965. J Med Chem. 2009. PMID: 19226162
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.
Randolph JT, Huang PP, Flosi WJ, DeGoey D, Klein LL, Yeung CM, Flentge C, Sun M, Zhao C, Dekhtyar T, Mo H, Colletti L, Kati W, Marsh KC, Molla A, Kempf DJ. Randolph JT, et al. Among authors: klein ll. Bioorg Med Chem. 2006 Jun 15;14(12):4035-46. doi: 10.1016/j.bmc.2006.02.013. Epub 2006 Feb 28. Bioorg Med Chem. 2006. PMID: 16504523
Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.
Hutchinson DK, Rosenberg T, Klein LL, Bosse TD, Larson DP, He W, Jiang WW, Kati WM, Kohlbrenner WE, Liu Y, Masse SV, Middleton T, Molla A, Montgomery DA, Beno DW, Stewart KD, Stoll VS, Kempf DJ. Hutchinson DK, et al. Among authors: klein ll. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3887-90. doi: 10.1016/j.bmcl.2008.06.043. Epub 2008 Jun 18. Bioorg Med Chem Lett. 2008. PMID: 18599294
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ. Degoey DA, et al. Among authors: klein ll. J Med Chem. 2009 Apr 23;52(8):2571-86. doi: 10.1021/jm900044w. J Med Chem. 2009. PMID: 19323562
Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.
Randolph JT, Flentge CA, Huang PP, Hutchinson DK, Klein LL, Lim HB, Mondal R, Reisch T, Montgomery DA, Jiang WW, Masse SV, Hernandez LE, Henry RF, Liu Y, Koev G, Kati WM, Stewart KD, Beno DW, Molla A, Kempf DJ. Randolph JT, et al. Among authors: klein ll. J Med Chem. 2009 May 28;52(10):3174-83. doi: 10.1021/jm801485z. J Med Chem. 2009. PMID: 19402666
Enantioselective synthesis of antiinfluenza compound A-315675.
DeGoey DA, Chen HJ, Flosi WJ, Grampovnik DJ, Yeung CM, Klein LL, Kempf DJ. DeGoey DA, et al. Among authors: klein ll. J Org Chem. 2002 Aug 9;67(16):5445-53. doi: 10.1021/jo0162890. J Org Chem. 2002. PMID: 12153241
74 results