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IDH1 and IDH2 mutations in gliomas.
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. Yan H, et al. N Engl J Med. 2009 Feb 19;360(8):765-73. doi: 10.1056/NEJMoa0808710. N Engl J Med. 2009. PMID: 19228619 Free PMC article.
Mutant metabolic enzymes are at the origin of gliomas.
Yan H, Bigner DD, Velculescu V, Parsons DW. Yan H, et al. Cancer Res. 2009 Dec 15;69(24):9157-9. doi: 10.1158/0008-5472.CAN-09-2650. Cancer Res. 2009. PMID: 19996293 Free PMC article. Review.
IDH1 and IDH2: not your typical oncogenes.
Reitman ZJ, Parsons DW, Yan H. Reitman ZJ, et al. Among authors: yan h. Cancer Cell. 2010 Mar 16;17(3):215-6. doi: 10.1016/j.ccr.2010.02.024. Cancer Cell. 2010. PMID: 20227034 Free PMC article.
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, Friedman AH, Friedman H, Gallia GL, Giovanella BC, Grollman AP, He TC, He Y, Hruban RH, Jallo GI, Mandahl N, Meeker AK, Mertens F, Netto GJ, Rasheed BA, Riggins GJ, Rosenquist TA, Schiffman M, Shih IeM, Theodorescu D, Torbenson MS, Velculescu VE, Wang TL, Wentzensen N, Wood LD, Zhang M, McLendon RE, Bigner DD, Kinzler KW, Vogelstein B, Papadopoulos N, Yan H. Killela PJ, et al. Among authors: yan h. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6. doi: 10.1073/pnas.1303607110. Epub 2013 Mar 25. Proc Natl Acad Sci U S A. 2013. PMID: 23530248 Free PMC article.
Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.
Killela PJ, Pirozzi CJ, Healy P, Reitman ZJ, Lipp E, Rasheed BA, Yang R, Diplas BH, Wang Z, Greer PK, Zhu H, Wang CY, Carpenter AB, Friedman H, Friedman AH, Keir ST, He J, He Y, McLendon RE, Herndon JE 2nd, Yan H, Bigner DD. Killela PJ, et al. Among authors: yan h. Oncotarget. 2014 Mar 30;5(6):1515-25. doi: 10.18632/oncotarget.1765. Oncotarget. 2014. PMID: 24722048 Free PMC article.
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