Kotzsch A - Search Results

1

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.

Kotzsch A, Nickel J, Seher A, Sebald W, Müller TD. Kotzsch A, et al. EMBO J. 2009 Apr 8;28(7):937-47. doi: 10.1038/emboj.2009.37. Epub 2009 Feb 19. EMBO J. 2009. PMID: 19229295 Free PMC article.

2

A single residue of GDF-5 defines binding specificity to BMP receptor IB.

Nickel J, Kotzsch A, Sebald W, Mueller TD. Nickel J, et al. Among authors: kotzsch a. J Mol Biol. 2005 Jun 24;349(5):933-47. doi: 10.1016/j.jmb.2005.04.015. Epub 2005 Apr 22. J Mol Biol. 2005. PMID: 15890363

3

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

Weber D, Kotzsch A, Nickel J, Harth S, Seher A, Mueller U, Sebald W, Mueller TD. Weber D, et al. Among authors: kotzsch a. BMC Struct Biol. 2007 Feb 12;7:6. doi: 10.1186/1472-6807-7-6. BMC Struct Biol. 2007. PMID: 17295905 Free PMC article.

4

Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.

Saremba S, Nickel J, Seher A, Kotzsch A, Sebald W, Mueller TD. Saremba S, et al. Among authors: kotzsch a. FEBS J. 2008 Jan;275(1):172-83. doi: 10.1111/j.1742-4658.2007.06187.x. Epub 2007 Dec 6. FEBS J. 2008. PMID: 18070108 Free article.

5

Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.

Kotzsch A, Nickel J, Seher A, Heinecke K, van Geersdaele L, Herrmann T, Sebald W, Mueller TD. Kotzsch A, et al. J Biol Chem. 2008 Feb 29;283(9):5876-87. doi: 10.1074/jbc.M706029200. Epub 2007 Dec 26. J Biol Chem. 2008. PMID: 18160401 Free article.

6

Purification, crystallization and preliminary data analysis of ligand-receptor complexes of growth and differentiation factor 5 (GDF5) and BMP receptor IB (BRIB).

Kotzsch A, Nickel J, Sebald W, Mueller TD. Kotzsch A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):779-83. doi: 10.1107/S1744309109024142. Epub 2009 Jul 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19652338 Free PMC article.

7

A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity.

Harth S, Kotzsch A, Hu J, Sebald W, Mueller TD. Harth S, et al. Among authors: kotzsch a. PLoS One. 2010 Sep 28;5(9):e13049. doi: 10.1371/journal.pone.0013049. PLoS One. 2010. PMID: 20927405 Free PMC article.

8

Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA).

Nickel J, Kotzsch A, Sebald W, Mueller TD. Nickel J, et al. Among authors: kotzsch a. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):551-5. doi: 10.1107/S1744309111006907. Epub 2011 Apr 21. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21543859 Free PMC article.

9

Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Rα.

Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD. Patino E, et al. Among authors: kotzsch a. Structure. 2011 Dec 7;19(12):1864-75. doi: 10.1016/j.str.2011.08.015. Structure. 2011. PMID: 22153509 Free article.

10

GDF-5 can act as a context-dependent BMP-2 antagonist.

Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J. Klammert U, et al. Among authors: kotzsch a. BMC Biol. 2015 Sep 18;13:77. doi: 10.1186/s12915-015-0183-8. BMC Biol. 2015. PMID: 26385096 Free PMC article.

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