Hawtin RE - Search Results

1

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

Chen R, Wierda WG, Chubb S, Hawtin RE, Fox JA, Keating MJ, Gandhi V, Plunkett W. Chen R, et al. Among authors: hawtin re. Blood. 2009 May 7;113(19):4637-45. doi: 10.1182/blood-2008-12-190256. Epub 2009 Feb 20. Blood. 2009. PMID: 19234140 Free PMC article.

2

Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.

Chen R, Chubb S, Cheng T, Hawtin RE, Gandhi V, Plunkett W. Chen R, et al. Among authors: hawtin re. Cancer Res. 2010 Aug 15;70(16):6587-97. doi: 10.1158/0008-5472.CAN-09-3578. Epub 2010 Jul 27. Cancer Res. 2010. PMID: 20663900 Free PMC article.

3

SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE. Conroy A, et al. Among authors: hawtin re. Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. doi: 10.1007/s00280-008-0921-5. Epub 2009 Jan 24. Cancer Chemother Pharmacol. 2009. PMID: 19169685 Clinical Trial.

4

A phase 1b/2 study of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia.

Lancet JE, Roboz GJ, Cripe LD, Michelson GC, Fox JA, Leavitt RD, Chen T, Hawtin R, Craig AR, Ravandi F, Maris MB, Stuart RK, Karp JE. Lancet JE, et al. Haematologica. 2015 Feb;100(2):231-7. doi: 10.3324/haematol.2014.114769. Epub 2014 Nov 7. Haematologica. 2015. PMID: 25381131 Free PMC article. Clinical Trial.

5

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

Scatena CD, Kumer JL, Arbitrario JP, Howlett AR, Hawtin RE, Fox JA, Silverman JA. Scatena CD, et al. Among authors: hawtin re. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. doi: 10.1007/s00280-009-1234-z. Epub 2010 Jan 8. Cancer Chemother Pharmacol. 2010. PMID: 20058009 Free PMC article.

6

Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes.

Sherry B, Jain P, Chiu PY, Leung L, Allen SL, Kolitz JE, Rai KR, Barrientos J, Liang S, Hawtin R, Chiorazzi N. Sherry B, et al. Immunol Res. 2015 Dec;63(1-3):216-27. doi: 10.1007/s12026-015-8722-5. Immunol Res. 2015. PMID: 26478573 Free PMC article.

7

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. Hawtin RE, et al. PLoS One. 2010 Apr 15;5(4):e10186. doi: 10.1371/journal.pone.0010186. PLoS One. 2010. PMID: 20419121 Free PMC article.

8

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks.

Hawtin RE, Stockett DE, Wong OK, Lundin C, Helleday T, Fox JA. Hawtin RE, et al. Oncotarget. 2010 Nov;1(7):606-619. doi: 10.18632/oncotarget.195. Oncotarget. 2010. PMID: 21317456 Free PMC article.

9

Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP).

Rosen DB, Leung LY, Louie B, Cordeiro JA, Conroy A, Shapira I, Fields SZ, Cesano A, Hawtin RE. Rosen DB, et al. Among authors: hawtin re. J Transl Med. 2014 Jun 25;12:184. doi: 10.1186/1479-5876-12-184. J Transl Med. 2014. PMID: 24965603 Free PMC article.

10

Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.

Rosen DB, Cordeiro JA, Cohen A, Lacayo N, Hogge D, Hawtin RE, Cesano A. Rosen DB, et al. Among authors: hawtin re. Leuk Res. 2012 Jul;36(7):900-4. doi: 10.1016/j.leukres.2012.02.022. Epub 2012 Apr 21. Leuk Res. 2012. PMID: 22521550

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