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A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis.
Dagia NM, Kamath DV, Bhatt P, Gupte RD, Dadarkar SS, Fonseca L, Agarwal G, Chetrapal-Kunwar A, Balachandran S, Srinivasan S, Bose J, Pari K, B-Rao C, Parkale SS, Gadekar PK, Rodge AH, Mandrekar N, Vishwakarma RA, Sharma S. Dagia NM, et al. Eur J Pharmacol. 2009 Apr 1;607(1-3):201-12. doi: 10.1016/j.ejphar.2009.02.031. Epub 2009 Feb 21. Eur J Pharmacol. 2009. PMID: 19239912
A novel mTOR inhibitor is efficacious in a murine model of colitis.
Bhonde MR, Gupte RD, Dadarkar SD, Jadhav MG, Tannu AA, Bhatt P, Bhatia DR, Desai NK, Deore V, Yewalkar N, Vishwakarma RA, Sharma S, Kumar S, Dagia NM. Bhonde MR, et al. Among authors: dagia nm. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1237-45. doi: 10.1152/ajpgi.90537.2008. Epub 2008 Oct 16. Am J Physiol Gastrointest Liver Physiol. 2008. PMID: 18927209 Free article.
Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.
Balachandran S, Rodge A, Gadekar PK, Yadav VN, Kamath D, Chetrapal-Kunwar A, Bhatt P, Srinivasan S, Sharma S, Vishwakarma RA, Dagia NM. Balachandran S, et al. Among authors: dagia nm. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4773-6. doi: 10.1016/j.bmcl.2009.06.052. Epub 2009 Jun 17. Bioorg Med Chem Lett. 2009. PMID: 19592246
Synthesis and biological activity of novel MIF antagonists.
Balachandran S, Gadekar PK, Parkale S, Yadav VN, Kamath D, Ramaswamy S, Sharma S, Vishwakarma RA, Dagia NM. Balachandran S, et al. Among authors: dagia nm. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1508-11. doi: 10.1016/j.bmcl.2010.12.127. Epub 2011 Jan 1. Bioorg Med Chem Lett. 2011. PMID: 21277206
Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.
Deore V, Yewalkar N, Bhatia D, Desai N, Gupte RD, Dadarkar SS, Jadhav MG, Tannu AA, Bhatt P, Nemmani KV, Vishwakarma RA, Sharma S, Roychowdhury A, Dagia NM, Bhonde MR, Kumar S. Deore V, et al. Among authors: dagia nm. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2949-52. doi: 10.1016/j.bmcl.2009.04.055. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19409777
A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner.
Dagia NM, Agarwal G, Kamath DV, Chetrapal-Kunwar A, Gupte RD, Jadhav MG, Dadarkar SS, Trivedi J, Kulkarni-Almeida AA, Kharas F, Fonseca LC, Kumar S, Bhonde MR. Dagia NM, et al. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. doi: 10.1152/ajpcell.00461.2009. Epub 2010 Jan 20. Am J Physiol Cell Physiol. 2010. PMID: 20089935 Free article.
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