Chamberlin AR - Search Results

1

Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues.

Qiu XL, Li G, Wu G, Zhu J, Zhou L, Chen PL, Chamberlin AR, Lee WH. Qiu XL, et al. Among authors: chamberlin ar. J Med Chem. 2009 Mar 26;52(6):1757-67. doi: 10.1021/jm8015969. J Med Chem. 2009. PMID: 19243176 Free PMC article.

2

Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.

Hu CM, Zhu J, Guo XE, Chen W, Qiu XL, Ngo B, Chien R, Wang YV, Tsai CY, Wu G, Kim Y, Lopez R, Chamberlin AR, Lee EY, Lee WH. Hu CM, et al. Among authors: chamberlin ar. Oncogene. 2015 Mar 5;34(10):1220-30. doi: 10.1038/onc.2014.67. Epub 2014 Mar 24. Oncogene. 2015. PMID: 24662830 Free PMC article.

3

Stereoselective synthesis of chiral IBR2 analogues.

Qiu XL, Zhu J, Wu G, Lee WH, Chamberlin AR. Qiu XL, et al. Among authors: chamberlin ar. J Org Chem. 2009 Mar 6;74(5):2018-27. doi: 10.1021/jo802607f. J Org Chem. 2009. PMID: 19191556

4

Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.

Zhu J, Chen H, Guo XE, Qiu XL, Hu CM, Chamberlin AR, Lee WH. Zhu J, et al. Among authors: chamberlin ar. Eur J Med Chem. 2015;96:196-208. doi: 10.1016/j.ejmech.2015.04.021. Epub 2015 Apr 9. Eur J Med Chem. 2015. PMID: 25874343 Free PMC article.

5

A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.

Zhu J, Zhou L, Wu G, Konig H, Lin X, Li G, Qiu XL, Chen CF, Hu CM, Goldblatt E, Bhatia R, Chamberlin AR, Chen PL, Lee WH. Zhu J, et al. Among authors: chamberlin ar. EMBO Mol Med. 2013 Mar;5(3):353-65. doi: 10.1002/emmm.201201760. Epub 2013 Jan 22. EMBO Mol Med. 2013. PMID: 23341130 Free PMC article.

6

The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity.

Aggen JB, Humphrey JM, Gauss CM, Huang HB, Nairn AC, Chamberlin AR. Aggen JB, et al. Among authors: chamberlin ar. Bioorg Med Chem. 1999 Mar;7(3):543-64. doi: 10.1016/s0968-0896(98)00254-5. Bioorg Med Chem. 1999. PMID: 10220039

7

Design, synthesis, and biological evaluation of chicoric acid analogs as inhibitors of HIV-1 integrase.

Charvat TT, Lee DJ, Robinson WE, Chamberlin AR. Charvat TT, et al. Among authors: chamberlin ar. Bioorg Med Chem. 2006 Jul 1;14(13):4552-67. doi: 10.1016/j.bmc.2006.02.030. Epub 2006 Mar 9. Bioorg Med Chem. 2006. PMID: 16524737

8

Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Hart ME, Chamberlin AR, Walkom C, Sakoff JA, McCluskey A. Hart ME, et al. Among authors: chamberlin ar. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1969-73. doi: 10.1016/j.bmcl.2004.01.093. Bioorg Med Chem Lett. 2004. PMID: 15050639

9

Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model.

Kaur P, Chamberlin AR, Poulos TL, Sevrioukova IF. Kaur P, et al. Among authors: chamberlin ar. J Med Chem. 2016 May 12;59(9):4210-20. doi: 10.1021/acs.jmedchem.5b01146. Epub 2015 Sep 24. J Med Chem. 2016. PMID: 26371436 Free PMC article.

10

The microcystins and nodularins: cyclic polypeptide inhibitors of PP1 and PP2A.

Gulledgea BM, Aggena JB, Huangb HB, Nairnc AC, Chamberlin AR. Gulledgea BM, et al. Among authors: chamberlin ar. Curr Med Chem. 2002 Nov;9(22):1991-2003. doi: 10.2174/0929867023368845. Curr Med Chem. 2002. PMID: 12369867 Review.

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