Hickey MJ - Search Results

1

Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus.

Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN. Love RA, et al. Among authors: hickey mj. J Virol. 2009 May;83(9):4395-403. doi: 10.1128/JVI.02352-08. Epub 2009 Feb 25. J Virol. 2009. PMID: 19244328 Free PMC article.

2

Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.

Love RA, Parge HE, Yu X, Hickey MJ, Diehl W, Gao J, Wriggers H, Ekker A, Wang L, Thomson JA, Dragovich PS, Fuhrman SA. Love RA, et al. Among authors: hickey mj. J Virol. 2003 Jul;77(13):7575-81. doi: 10.1128/jvi.77.13.7575-7581.2003. J Virol. 2003. PMID: 12805457 Free PMC article.

3

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.

Li H, Tatlock J, Linton A, Gonzalez J, Borchardt A, Dragovich P, Jewell T, Prins T, Zhou R, Blazel J, Parge H, Love R, Hickey M, Doan C, Shi S, Duggal R, Lewis C, Fuhrman S. Li H, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4834-8. doi: 10.1016/j.bmcl.2006.06.065. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824756

4

Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.

Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD Jr, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Himmel DM, et al. Among authors: hickey mj. Structure. 2009 Dec 9;17(12):1625-1635. doi: 10.1016/j.str.2009.09.016. Structure. 2009. PMID: 20004166 Free PMC article.

5

In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

Shi ST, Herlihy KJ, Graham JP, Fuhrman SA, Doan C, Parge H, Hickey M, Gao J, Yu X, Chau F, Gonzalez J, Li H, Lewis C, Patick AK, Duggal R. Shi ST, et al. Antimicrob Agents Chemother. 2008 Feb;52(2):675-83. doi: 10.1128/AAC.00834-07. Epub 2007 Dec 10. Antimicrob Agents Chemother. 2008. PMID: 18070954 Free PMC article.

6

Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.

Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Li H, et al. J Med Chem. 2009 Mar 12;52(5):1255-8. doi: 10.1021/jm8014537. J Med Chem. 2009. PMID: 19209845

7

Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone.

Kung PP, Huang B, Zhang G, Zhou JZ, Wang J, Digits JA, Skaptason J, Yamazaki S, Neul D, Zientek M, Elleraas J, Mehta P, Yin MJ, Hickey MJ, Gajiwala KS, Rodgers C, Davies JF, Gehring MR. Kung PP, et al. Among authors: hickey mj. J Med Chem. 2010 Jan 14;53(1):499-503. doi: 10.1021/jm901209q. J Med Chem. 2010. PMID: 19908836

8

Solution-phase parallel synthesis of Hsp90 inhibitors.

Cho-Schultz S, Patten MJ, Huang B, Elleraas J, Gajiwala KS, Hickey MJ, Wang J, Mehta PP, Kang P, Gehring MR, Kung PP, Sutton SC. Cho-Schultz S, et al. Among authors: hickey mj. J Comb Chem. 2009 Sep-Oct;11(5):860-74. doi: 10.1021/cc900056d. J Comb Chem. 2009. PMID: 19583220

9

Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).

Murphy ST, Alton G, Bailey S, Baxi SM, Burke BJ, Chappie TA, Ermolieff J, Ferre R, Greasley S, Hickey M, Humphrey J, Kablaoui N, Kath J, Kazmirski S, Kraus M, Kupchinsky S, Li J, Lingardo L, Marx MA, Richter D, Tanis SP, Tran K, Vernier W, Xie Z, Yin MJ, Yu XH. Murphy ST, et al. Among authors: hickey m. J Med Chem. 2011 Dec 22;54(24):8490-500. doi: 10.1021/jm201019k. Epub 2011 Nov 23. J Med Chem. 2011. PMID: 22040023

10

Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.

Kung PP, Sinnema PJ, Richardson P, Hickey MJ, Gajiwala KS, Wang F, Huang B, McClellan G, Wang J, Maegley K, Bergqvist S, Mehta PP, Kania R. Kung PP, et al. Among authors: hickey mj. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3557-62. doi: 10.1016/j.bmcl.2011.04.130. Epub 2011 May 5. Bioorg Med Chem Lett. 2011. PMID: 21612924

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