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One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength.
Ominsky MS, Stolina M, Li X, Corbin TJ, Asuncion FJ, Barrero M, Niu QT, Dwyer D, Adamu S, Warmington KS, Grisanti M, Tan HL, Ke HZ, Simonet WS, Kostenuik PJ. Ominsky MS, et al. Among authors: stolina m. J Bone Miner Res. 2009 Jul;24(7):1234-46. doi: 10.1359/jbmr.090215. J Bone Miner Res. 2009. PMID: 19257823 Free article.
RANKL inhibition: from mice to men (and women).
Stolina M, Kostenuik PJ, Dougall WC, Fitzpatrick LA, Zack DJ. Stolina M, et al. Adv Exp Med Biol. 2007;602:143-50. doi: 10.1007/978-0-387-72009-8_18. Adv Exp Med Biol. 2007. PMID: 17966399 Review.
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.
Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, Kurahara C, Gao Y, Cao J, Gong J, Asuncion F, Barrero M, Warmington K, Dwyer D, Stolina M, Morony S, Sarosi I, Kostenuik PJ, Lacey DL, Simonet WS, Ke HZ, Paszty C. Li X, et al. Among authors: stolina m. J Bone Miner Res. 2008 Jun;23(6):860-9. doi: 10.1359/jbmr.080216. J Bone Miner Res. 2008. PMID: 18269310 Free article.
RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats.
Ominsky MS, Li X, Asuncion FJ, Barrero M, Warmington KS, Dwyer D, Stolina M, Geng Z, Grisanti M, Tan HL, Corbin T, McCabe J, Simonet WS, Ke HZ, Kostenuik PJ. Ominsky MS, et al. Among authors: stolina m. J Bone Miner Res. 2008 May;23(5):672-82. doi: 10.1359/jbmr.080109. J Bone Miner Res. 2008. PMID: 18433301 Free article.
88 results