Friedlos F - Search Results

1

Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species.

Knox RJ, Friedlos F, Marchbank T, Roberts JJ. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1991 Oct 9;42(9):1691-7. doi: 10.1016/0006-2952(91)90503-w. Biochem Pharmacol. 1991. PMID: 1930294

2

The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink.

Friedlos F, Quinn J, Knox RJ, Roberts JJ. Friedlos F, et al. Biochem Pharmacol. 1992 Mar 17;43(6):1249-54. doi: 10.1016/0006-2952(92)90499-9. Biochem Pharmacol. 1992. PMID: 1562278

3

Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.

Roberts JJ, Marchbank T, Kotsaki-Kovatsi VP, Boland MP, Friedlos F, Knox RJ. Roberts JJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1989 Nov 15;38(22):4137-43. doi: 10.1016/0006-2952(89)90695-3. Biochem Pharmacol. 1989. PMID: 2480794

4

The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).

Knox RJ, Boland MP, Friedlos F, Coles B, Southan C, Roberts JJ. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1988 Dec 15;37(24):4671-7. doi: 10.1016/0006-2952(88)90336-x. Biochem Pharmacol. 1988. PMID: 3144286

5

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells.

Knox RJ, Friedlos F, Jarman M, Roberts JJ. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1988 Dec 15;37(24):4661-9. doi: 10.1016/0006-2952(88)90335-8. Biochem Pharmacol. 1988. PMID: 3202902

6

Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: relationship to toxicity.

Roberts JJ, Friedlos F. Roberts JJ, et al. Among authors: friedlos f. Pharmacol Ther. 1987;34(2):215-46. doi: 10.1016/0163-7258(87)90012-x. Pharmacol Ther. 1987. PMID: 3317452 Review. No abstract available.

7

CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells.

Roberts JJ, Friedlos F, Knox RJ. Roberts JJ, et al. Among authors: friedlos f. Biochem Biophys Res Commun. 1986 Nov 14;140(3):1073-8. doi: 10.1016/0006-291x(86)90744-8. Biochem Biophys Res Commun. 1986. PMID: 3778483

8

Virtual cofactors for an Escherichia coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Jarman M, Davies LC, Goddard P, Anlezark GM, Melton RG, Sherwood RF. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1995 May 26;49(11):1641-7. doi: 10.1016/0006-2952(95)00077-d. Biochem Pharmacol. 1995. PMID: 7786305

9

Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954.

Knox RJ, Friedlos F, Biggs PJ, Flitter WD, Gaskell M, Goddard P, Davies L, Jarman M. Knox RJ, et al. Among authors: friedlos f. Biochem Pharmacol. 1993 Sep 1;46(5):797-803. doi: 10.1016/0006-2952(93)90487-h. Biochem Pharmacol. 1993. PMID: 8373433

10

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

Knox RJ, Friedlos F, Boland MP. Knox RJ, et al. Among authors: friedlos f. Cancer Metastasis Rev. 1993 Jun;12(2):195-212. doi: 10.1007/BF00689810. Cancer Metastasis Rev. 1993. PMID: 8375021 Review.

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