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Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.
Roberts JJ, Marchbank T, Kotsaki-Kovatsi VP, Boland MP, Friedlos F, Knox RJ. Roberts JJ, et al. Biochem Pharmacol. 1989 Nov 15;38(22):4137-43. doi: 10.1016/0006-2952(89)90695-3. Biochem Pharmacol. 1989. PMID: 2480794
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).
Knox RJ, Boland MP, Friedlos F, Coles B, Southan C, Roberts JJ. Knox RJ, et al. Among authors: roberts jj. Biochem Pharmacol. 1988 Dec 15;37(24):4671-7. doi: 10.1016/0006-2952(88)90336-x. Biochem Pharmacol. 1988. PMID: 3144286
A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to a cytotoxic DNA interstrand crosslinking agent by reduction of its 4-nitro group to the corresponding hydroxylamino species (Robe …
A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1 …
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells.
Knox RJ, Friedlos F, Jarman M, Roberts JJ. Knox RJ, et al. Among authors: roberts jj. Biochem Pharmacol. 1988 Dec 15;37(24):4661-9. doi: 10.1016/0006-2952(88)90335-8. Biochem Pharmacol. 1988. PMID: 3202902
CB 1954 forms DNA interstrand crosslinks in a time-dependent manner in Walker tumour cells but not in non-toxically affected Chinese hamster V79 cells [(Roberts JJ et al., Biochem Biophys Res Commun 140: 1073-1078, 1986)]. However, co-culturing Chinese hamster V79 c …
CB 1954 forms DNA interstrand crosslinks in a time-dependent manner in Walker tumour cells but not in non-toxically affected Chinese hamster …
150 results